Bordetella

Question 1

Bordetella is a gram ______ bacteria.

Answer 1

Negative

[small, cocco-bacillus]

Question 2

True/False. Bordetella is an obligate symbiotic and facultative pathogenic bacteria.

Answer 2

True

Question 3

Which species of Bordetella is associated with whooping cough in humans?

Answer 3

B. pertussis and B. parapertussis

[Tuss-cough]

Question 4

Which species of Bordetella is important in animals/is the only one that the powerpoint goes into detail on?

Answer 4

B. bronciseptica

[also lists B. avium]

Question 5

True/False. B. brochiseptica is an aerobic bacteria.

Answer 5

True.

Question 6

What kind of tissue does B. bronciseptica have an affinity for?

Answer 6

Ciliated respiratory epithelium in the URT of many animals species

Question 7

What is the main adhesion virulence factor for B. bronchiseptica?

Answer 7

Filamentous hemagglutinin

[adhesion to ciliated respiratory epithelia and also macrophages]

Question 8

Which toxin produced by B. bronciseptica and also by P. multocida?

Answer 8

Demonecrotic toxin (DNT)

B. bronciseptica DNT - damages osteoblasts

P. multocida DNT - damages osetoclasts

Question 9

Which toxin produced by B. bronciseptica is responsible for the destruction of ciliated respiratory epithelium?

Answer 9

Tracheal cytotoxin

Question 10

Which part of B. bronchiseptica is responsible for phase variation between the virulent and non-virulent phase?

Answer 10

Bvg regulon

Question 11

What diseases does B. bronciseptica cause in pigs?

Answer 11

Non-progressive atrophic rhinitis

Pneumonic bordetellosis

Progressive atrophic rhinitis (with P. multocida)

Question 12

What diesase does B. bronciseptica cause in dogs? Can cats become infected?

Answer 12

Canine infectious tracheobroncitis (kennel cough)

Kittens can become infected but older cats not as susceptible and the disease will be mild

Question 13

Can you vx pigs for B. bronchiseptica?

Answer 13

Yes, vx sows, vx has questionable efficacy in piglets

Question 14

Can you vaccinate dogs for B. bronchiseptica?

Answer 14

Yes. Inactivated (injectable) and live (IN)

Question 15

Can horses become infected with B. bronchiseptica? How would you prevent infection if they can?

Answer 15

Yes but its very rare - symptoms similar to cats and dogs

Prevention of dust and inhalation of spores from hay

Question 16

Which species are most animals carriers for B. bronciseptica?

Answer 16

Rabbits

Question 17

Which species of Bordetella will infect poultry? Which species of poultry does it commonly infect and what diesase does it cause?

Answer 17

B. avium

Infects turkeys and causes Coryza

Question 18

Which antibiotics are toxic to rabbits?

Answer 18

Lincosamides: clindamycin and lincomycin

Single dose = 100% mortality

[to a lesser degree penicillins and macrolides]

Question 19

Which bacteria with B. bronchiseptica causes bronchopneuomia in rabbits?

Answer 19

P. multocida