Bordetella Flashcards
Bordetella is a gram ______ bacteria.
Negative
[small, cocco-bacillus]
True/False. Bordetella is an obligate symbiotic and facultative pathogenic bacteria.
True
Which species of Bordetella is associated with whooping cough in humans?
B. pertussis and B. parapertussis
[Tuss-cough]
Which species of Bordetella is important in animals/is the only one that the powerpoint goes into detail on?
B. bronciseptica
[also lists B. avium]
True/False. B. brochiseptica is an aerobic bacteria.
True.
What kind of tissue does B. bronciseptica have an affinity for?
Ciliated respiratory epithelium in the URT of many animals species
What is the main adhesion virulence factor for B. bronchiseptica?
Filamentous hemagglutinin
[adhesion to ciliated respiratory epithelia and also macrophages]
Which toxin produced by B. bronciseptica and also by P. multocida?
Demonecrotic toxin (DNT)
B. bronciseptica DNT - damages osteoblasts
P. multocida DNT - damages osetoclasts
Which toxin produced by B. bronciseptica is responsible for the destruction of ciliated respiratory epithelium?
Tracheal cytotoxin
Which part of B. bronchiseptica is responsible for phase variation between the virulent and non-virulent phase?
Bvg regulon
What diseases does B. bronciseptica cause in pigs?
Non-progressive atrophic rhinitis
Pneumonic bordetellosis
Progressive atrophic rhinitis (with P. multocida)
What diesase does B. bronciseptica cause in dogs? Can cats become infected?
Canine infectious tracheobroncitis (kennel cough)
Kittens can become infected but older cats not as susceptible and the disease will be mild
Can you vx pigs for B. bronchiseptica?
Yes, vx sows, vx has questionable efficacy in piglets
Can you vaccinate dogs for B. bronchiseptica?
Yes. Inactivated (injectable) and live (IN)
Can horses become infected with B. bronchiseptica? How would you prevent infection if they can?
Yes but its very rare - symptoms similar to cats and dogs
Prevention of dust and inhalation of spores from hay
Which species are most animals carriers for B. bronciseptica?
Rabbits
Which species of Bordetella will infect poultry? Which species of poultry does it commonly infect and what diesase does it cause?
B. avium
Infects turkeys and causes Coryza
Which antibiotics are toxic to rabbits?
Lincosamides: clindamycin and lincomycin
Single dose = 100% mortality
[to a lesser degree penicillins and macrolides]
Which bacteria with B. bronchiseptica causes bronchopneuomia in rabbits?
P. multocida
