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Ronnie's lectures > Blood Brain barrier > Flashcards

Blood Brain barrier Flashcards

1
Q

Where is the BBB located?

A

In the blood capillary

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2
Q

What are the cellular components of the BBB?

A
  • Endothelial cell
  • Pericyte
  • Astrocyte
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3
Q

What does the preicyte do?

A

-They are contractile cells that wrap around the endothelial cells that line the capillaries and venules

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4
Q

The pericyte and astrocytes wrap around the barrier making it tight. TRUE OR FALSE?

A

TRUE

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5
Q

The capillaries form 95% of the BBB. TRUE OR FALSE?

A

TRUE

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6
Q

What does the endothelial cell line?

A

They line the capillaries

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7
Q

What are endothelial cells surrounded by?

A
  • Collagen
  • Fibronectin
  • Laminin
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8
Q

What does the astrocyte foot processes secrete?

A

-Paracrines that promote tight junction formation

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9
Q

Tight junctions do not prevent solute movement between endothelial cells. TRUE OR FALSE?

A

FALSE

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10
Q

What two types of proetins are found in a tight junction?

A
  • Intergral membrane proteins

- Cytoplasmic accessory proteins

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11
Q

LIst the differences between Intergral membrane proteins and Cytoplasmic accessory proteins

A

Intergral membrane proteins:

  • Claudin
  • Occludin
  • Junctional adhesion molecule

Cytoplasmic accessory proteins

  • Zonula occludens
  • Cingulin
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12
Q

What is the function of arachnoid cells?

A

Helps keep the content of the central nervous system stabilized (i.e prevent movement)

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13
Q

How much CSF is in the brain?

A

100-160ml

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14
Q

How much CSF does the brain produce per day?

A

500ml

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15
Q

What is the rate of CSF replacement?

A

about 4 times

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16
Q

What the functions for CSF?

A
  • Provide mechanical protection
  • Maintain a stable extracellular environment for the brain
  • Removes some waste products
  • Nutrition
  • Convey messages / hormone releasing factors/NT
17
Q

What are the different types of transport mechanism that occur in the BBB?

A
  • Passive diffusion
  • ABC transporter efflux
  • Solute carriers SLC
  • Transcytosis receptor mediated adsorptive mediated
  • Mononuclear cell migration
18
Q

What type of molecules are transported across the different types of transport mechanism?

A 
-Passive diffusion
 (lipid soluble/non polar molecules)
-ABC transporter efflux 
(lipid soluble/non polar molecules and conjugates)
-Solute carriers SLC 
(Glucose/AAs/Nucleosides)
-Transcytosis receptor mediated adsorptive mediated (Transferrin/lipoproteins/insulin/IgG)  
- Mononuclear cell migration 
(Cationised albumin/histone)
19
Q

Drugs/Molecules that are more lipohilic will have greater permeability tthan drugs that are more hydrophilic. TRUE OR FALSE?

A

TRUE

20
Q

Which of these, glucose, lactate, essential AAs or organic anion transporter cannot cross into the blood but can cross into the brain?

A

organic anion transporter

21
Q

What is transcytosis?

A

Endocytosis + Exocytosis

22
Q

Give examples of receptor mediated transcytosis?

A

Transferrin
Insulin
Erythropoietin

23
Q

Give an example of an adsorptive mediated transcytosis?

A

Albumin

24
Q

What type of molecules are not permitted to enter into the brain?

A
  • Large molecules
  • Low lipid soluble molecules
  • High electrical charge
25
Q

What are the functions of the BBB?

A
  • Protects the brain from foreign substances in the blood that may cause injury to the brain
  • Protects the brain from hormones and NT in the rest of the body
  • Transports nutrients into the brain
  • Move out toxins of the brain
  • Maintains a constant environment for the brain
  • Essential for brain normal functions
26
Q

The BBB is permeable to small and lipophilic molecules. TRUE OR FALSE/

A

TRUE

27
Q

Larger molecules are not transported across unless there is an active transport system available. TRUE OR FALSE/

A

TRUE

28
Q

What occurs in efflux drug systems and give an example?

A

Drugs are pumped back out of cells

e.g P-gly-coprotein-p-gp

29
Q

A large proportion of drugs can cross the BBB. TRUE OR FALSE?

A

FALSE

30
Q

What are the strategies of delivering drugs to the brain?

A 
Go through:
-the use of endogenous system 
-disturbing the BBB
-Produgs 
Go behind:
-Intraventricular/intrathecal route 
-olfactory pathway 
-interstitial delivery

Ronnie's lectures (12 decks)

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