Blood & Blood Products (ASAN002/15) Flashcards

1
Q

Aim of Blood Transfusion:

A

To ↑ the O² carrying capacity of the blood due to ↓ in circulating RBC’s, which contain haemoglobin that carries O² to the body.

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2
Q

Blood & Blood Products:

A

Blood & Blood Products available:\nFresh whole blood\nStored whole blood\nPacked RBC’s\nFresh frozen plasma\nFrozen plazma\nPlatelet–rich plasma\nCryoprecipitate

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3
Q

Commonly used Blood Products:

A

Fresh whole blood (FWB)\nStored whole blood (SWB)\nPacked RBC’s\nFresh Frozen Plasma (FFP)\nFrozen Plasma (FP)

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4
Q

Fresh Whole Blood (FWB)

A

Collected immediately prior to transfusion (preferably).

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5
Q

FWB – Units:

A

A ‘unit’ of blood refers to the standard measure of blood for a species.\nCanine unit = ∽500mls\nFeline unit = ∽50–60mls

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6
Q

FWB Contains:

A

RBC’s\nWBC’s\nClotting factors\nPlatelets

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7
Q

FWB Dose:

A

2.2ml/kg will ↑ PCV by 1% (‘rule of thumb’)\nCorrect dose calculations are also available (later in notes)

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8
Q

FWB Time:

A

Use ASAP – preferably within 4hrs\nDo not refrigerate

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9
Q

FWB Use:

A

Replacement of RBC, platelets & clotting factors.

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10
Q

Stored Whole Blood (SWB)

A

Blood used <8hrs after collection, or stored once collected.

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11
Q

SWB Contains:

A

RBC’s\nWBC’s\nPlasma proteins

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12
Q

SWB Dose:

A

2.2ml/kg will ↑ PCV by 1% (‘rule of thumb’)\nCorrect dose calculations are also available (later in notes)

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13
Q

SWB Storage:

A

Store at 1 – 6 ℃\nWill last 28 – 35 days (in appropriate blood collection bags, e.g. CPDA–1)\nAgitate daily

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14
Q

SWB Use:

A

Replacement of RBC’s\nVolume replacement

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15
Q

Packed Red Blood Cells

A

Whole blood is centrifuged & separated into plasma & RBC’s following collection.

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16
Q

Packed RBC’s Contains:

A

RBC’s only\nOften diluted with sterile NaCl prior to transfusion.

17
Q

Packed RBC’s Dose:

A

2.0ml/kg will ↑ PCV by 2% (‘rule of thumb’)\nCorrect dose calculations are also available (later in notes)

18
Q

Packed RBC’s Storage:

A

Store at 1 – 6 ℃\n28 – 35 days\nAgitate daily

19
Q

Packed RBC’s Use:

A

Replacement of RBC’s\nVolume replacement

20
Q

Fresh Frozen Plasma (FFP)

A

Plasma that is frozen within 6hrs of collection.

21
Q

FFP Contains:

A

Clotting factors\nVitamin K factors\nPlasma proteins

22
Q

FFP Dose:

A

45ml/kg will increase albumin by ∽ 1g/dl

23
Q

FFP Storage:

A

Store at –20 to – 30℃\nRemain viable for 1yr

24
Q

FFP Use:

A

Replacement clotting factors\nReplacement of plasma proteins (hypoproteinaemia)

25
Q

Frozen Plasma (FP)

A

Plasma that is frozen 6– 8 hrs post collection, or frozen for over 1yr.

26
Q

FP Contains:

A

Plasma protiens\nVitamin K factors

27
Q

FP Storage:

A

Store at –20 to – 30℃\nViable for 4 yrs

28
Q

FP Use:

A

Replacement of plasma proteins\nVitamin K factors

29
Q

Other Blood Products

A

Platelet–rich Plasma & Platelet Concentrate\nCryoprecipitate

30
Q

Platelet–rich Plasma & Platelet Concentrate

A

Is harvested by centrifuging FWB at a slower rate than that used for the production of packed RBC’s & plasma.\nBlood needs to be centrifuged at room temperature – refrigeration causes platelet dysfunction.

31
Q

Platelet–rich Plasma Contains:

A

Platelets\nCoagulation factors\nPlasma proteins

32
Q

Platelet–rich Plasma Storage:

A

Difficult to store\nShort life span\nUse within 48hrs if kept at room temp & protected from light.

33
Q

Cryoprecipitate

A

Prepared by using 1 unit FFP & a triple bag collection system.\nCryoprecipitate is the cold, insoluble portion of plasma that forms after FFP has been thawed slowly in the refrigerator over 12 – 16hrs.\nIt’s separation & collection is quite complex.

34
Q

Cryoprecipitate Contains:

A

Von Willebrand Factor\nFibrinogen\nFactor VIII

35
Q

Cryoprecipitate Uses:

A

Mainly used to treat von Willebrand’s disease.