Blood Flashcards
What are the three constituents of the blood?
1) Plasma 56%
2) Erythrocytes (43%)
3) Leucocytes (1%)
What is serum?
Plasma without clotting factors
What is included in plasma? (5)
1) Water 2) Salts/minerals
3) plasma proteins 4) Hormones 5) Clotting factors
Where are erythrocytes produced and destroyed?
1) Produced: Liver (fetus) and H. B Marrow
2) Destroyed in liver and spleen
What is life span, size and endoskeleton in RBC?
120 days, 7-8um, Spectrin
3 categories of Leucocytes?
1) Granulocytes (Neut, Eosin, Baso)
2) Agranulocytes (Lymph and Mono)
3) Platelets
What is the most common white blood cell, its diameter and function? (3)
1) Neutrophil
2) 12-14 um
3) Invade tissue
Size of eosinophil, function and 2 features?
1) 12-17 um 2) Neutralise histamine
3) Increase in parasitic infections
3) Large red cytoplasmic granules with crystalline inclusions
Size and functions of basophils?
1) 14-16 um
2) Produce histamine, agglutination and coagulation
How do lymphocytes appear on a slide?
large clear blue/grey cytoplasm
2 Derivatives of Lymphocytes?
1) B: Plasma and secrete AB
2) T cells: Immunity (Immunohistochemistry to identify)
Size, function and feature of monocytes?
1) 15-20um
2) Immature, with reniform nucleus
3) Differentiate into several cell types e.g. A Presenting
Size, derived from and function of platelets?
1) 1-3 um 2) Megakaryocytes
3) Coagulation (Thrombosis)
2 differentiations of Haematopoesis?
1) Myeloid progenitor (WBC and RBC)
2) Lymphoid progenitor (Lymphocytes)
3 cell lines?
1) Myelon (WBC) 2) Erythron (RBC)
3) Megakaryocytes (Platelets)
What happens in Granulopoesis?
Increase in number of granules and complex shape, pool of stored matured neutrophils in bone marrow
What happens in Erythropoiesis?
Decrease cell size, HB produced, reduction and loss of organelles,
What stain is used to stain BC’s?
Romanovsky
Number of platelet and neutrophil granules?
3
When do reticulocytes (Immature BC) increase in number?
Following significant injury when lots of blood loss
