Block 6 - Psychological Medicine 2 Flashcards
2 characteristics of Schizophrenia
Relapsing
Remitting
What type of symptoms are thought disorder and decreased speech?
Thought disorder: +
Decreased speech: -
4 examples of extra pyramidal side effects
Acute Dystonia
Akathinisia
Parkinsons
Tardive Dyskinesia
Give 3 examples of infundibular side effects
How are they all caused?
Decreased periods, Decreased breast milk production, Infertility
Decrease in prolactin
Which disorder is classed as a syndrome?
Depression
What is the hypothesised cause of Schizophrenia?
+ symptoms: Increased dopamine in mesolimbic tracts
- symptoms: Decreased dopamine in mesocrotisol tracts
What are the arguments for and against the dopamine hypothesis of schizophrenia?
FOR: Antipsychotics work on domamine; drugs that increase dopamine cause psychosis, changes in dopamine activity on brain scans
AGAINST: Drugs take a while to work (another mechanism?)
What causes a hypertensive crisis when consumed with MAO’s
Tyramine
What is the hypothesised cause of depression?
4 other theories
Decreased in neurotransmitters that are broken down by MAO
Behavioural, cognitive, physiological and endocrine
What are the arguments for and against the MAO hypothesis for depression?
FOR: Drugs that decrease MAO work; there are less precursors to MAO neurotransmitters in the blood
AGAINST: Drugs take weeks to work, some drugs don’t target neurotransmiters, cocaine mimics neurotransmitters but is not an antidepressant
What do autoreceptors do?
Cancel out the effects of neurotransmitters
What hormone does anxiety increase the level of?
Cortisol
How do calcium ion changes occur when you are having a panic attack?
Decreased carbon dioxide levels
9 physiological symptoms of anxiety
Decreased concentration and memory
Fear, panic, worry, irritability
Fear of death, danger, losing control
5 unhelpful behaviours associated with anxiety
Avoidance, coping mechanisms (e.g. drugs), pacing, safety behaviours, wringing hands
Define learning
Permanent change in behaviour due to experience
What area of the brain is involved in learning?
Amygdala
Why do we learn?
To adapt and survive
What are the 4 types of learning?
Associative
Complex
Factual Transmission
Vicarious
What is associative learning?
2 e.g.
Learning that events come together
e.g. classical and operant
What is vicarious learning?
e.g.
Learning by observation
e.g. modelling
What is complex learning?
2 e.g.
Learning in social situation
e.g. emotional intelligence
What is factual transmission?
Doing things with information to incorporate it into your brain
What is the difference between continuous and partial conditioning?
Which is more common?
Continuous: Every experience is reinforced
Partial: Reinforcement doesn’t happen every time
Partial is more common
What are the four types of partial conditioning?
Interval schedules: Depends on the time interval
Fixed: Predictable
Ratio schedules: Depends on the number of responses
Variable: Unpredictable
Explain ‘Thornicke’s Law of Effect’
Successful behaviour will be repeated
The reinforcer is IMMEDIATELY linked
Give an example of a primary and secondary reinforcement mechanism
Primary: Food
Secondary: Money`
Define shaping
What type of reinforcement is it?
Rewarding smaller behaviours with the aim of rewarding the desired and more complex behaviour
Positive
Define chaining
What type of reinforcement is it?
Breaking down complex behaviours into a series of simple acts which reinforces the next
Positive
Define phobia
A marked and persistent fear triggered by a specific object/situation that leads to avoidance
What are the three types of phobia?
Agoraphobia
Social phobia
Specific phobia
Define Agoraphobia
Give and example
Fear of public places
e.g. crowds
Define social phobia
Give and example
Fear of public performance
e.g. eating in public
Define specific phobia
Give and example
Specific fear
e.g. spiders
What type of reinforcement maintains phobia?
Negative
What are SMART targets?
A set number of targets which each increase in difficulty to treat anxiety or phobias
4 problems with punishment
Aggression
Fear or person
Physical/emotional harm
May increase the behaviour (e.g. child knows they get attention if they are naughty)
What are the symptoms of depression?
mneumonic
Depressed mood Energy loss/fatigue Pleasure lost Retardation/agitation Eating changes Sleep changes Suicidal thoughts I'm a faliure (loss of self-esteem and confidence) Only me to blame (guilt) No concentration
What is Annedonia
Decrease in pleasure
What is the difference between the somatic and autonomic nervous system?
Somatic: External environment
Autonomic: Internal environment (systems and homeostasis)
What are the somatic nervous system neurones, neurotransmitters and effectors?
Neurones: Single LMN from the CNS
Neurotransmitter: Excitatory ACh
Effector: Skeletal muscle
What are the enteric nervous system plexuses?
Myenteric and submucosal
How is the enteric system up/down regulated?
By the parasympathetic and sympathetic nervous systems
What are the neurotransmitters and effectors for the autonomic nervous system?
Neurotransmitter: ACh and noradrenaline
Effector: Cardiac smooth muscle, glands and organs
Where are the pre and post ganglionic neurones for the autonomic nervous system?
Pre-ganglionic: CNS, horn cells and cranial nerve nuclei
Post-ganglionic: In the ganglia
Where do the preganglionic neurones from the parasympathetic nervous system arise from?
Cranial nerves 3, 7, 9 and 10
Where do the preganglionic neurones from the parasympathetic nervous system end?
S2-S4
lateral part
Where is the postganglionic neurone from the parasympathetic nervous system?
What does this mean for the lengths of the pre and post ganglionic neurones
Near the organ
The pre ganglionic neurone is a lot longer than the psot ganglionic neurone
2 places where preganglionic axons do not travel
Within rami communicants or spinal nerves
What class of neurones are in the parasympathetic nervous system? What are the differences between them?
Cholinergic
Post-ganglionic: Nicotinic
Pre-ganglionic: Muscarinic
What type of secretion is the parasympathetic nervous system responsible for?
Secretomotor
Where do the pelvic splanchnic nerves arise from?
S2-S4
What are the lengths of the pre and post ganglionic neurones in the sympathetic and parasympathetic nervous system?
Parasympathetic: The pre-ganglionic neurone is longer than the post ganglionic neurone
Sympathetic: The post-ganglionic neurone is longer than the pre-ganglionic neurone
What class of neurones are in the parasympathetic nervous system?
Post-ganglionic: Nicotinic cholinergic
Pre-ganglionic: Noradrenaline
Where are paravertebral ganglia?
Sympathetic trunk in the thorax
How do pre-ganglionic neurones leave the spinal cord and enter the body?
Pre-ganglionic neurones leave the spinal cord and enter the paravertebral sympathetic trunk
Spinal rami transport the pre-ganglionic neurones to the body
What does the adrenal medulla act as?
A ganglion with no post ganglionic neurones
What are the three thoracic splanchnic nerves?
Greater
Lesser
Least
What does the greater splanchnic nerve supply?
Coeliac ganglion
What does the lesser splanchnic nerve supply?
Superior mesenteric ganglion
What does the least splanchnic nerve supply?
Inferior mesenteric ganglion
Which post- ganglionic neurones release NO?
What does it lead to?
Nitroxidergic
Vasodilation
What is the role of the limbic system?
Emotions about neurological function
What is ptosis?
Lazy upper eyelid
What is anhydrosis?
No sweating on one side of the face
What is miosis?
Constricted pupil
Explain the parasympathetic and sympathetic control of the bladder?
Parasympathetic: Always excitatory
Sympathetic: Inhibitory to the muscle and excitatory to the sphincter
What is Brown-Sequard Syndrome?
Sensory loss (pain and temperature contralateral) and motor loss due to hemisection
9 side effects of overstimulating muscarinic and nicotinic neurones
3 for muscarinic specifically
4 for nicotinic specifically
Both: Diarrhoea, lacrimination, mitosis, perspiration, salivation, vomiting
Muscarinic: Bradycardia, coma, confusion
Nicotinic: Agitation, hypertension, tachycardia, tachypnoea
What is the structure of a muscarinic cholinergic receptor?
What type of response does it produce?
G protein receptor with 7 transmembrane protein that uses ATP to cause an indirect response
What is the structure of a nicotinic cholinergic receptor?
Ligand gated ion channels
What is the difference between uptake pathway 1 and 2?
Uptake pathway 1: Uptake at the neurone (e.g. breaking down the neurotransmitter)
Uptake pathway 2: Away from the neurone (e.g. MAO in liver)
How does the adrenal medulla release adrenaline?
Adds a methyl group
Which adrenergic neurone does adrenaline mainly work on?
Beta
What is the structure of an adrenergic receptor?
7 transmembrane G protein
What two behaviours are impaired in a learning disability
Adaptive behaviour (reading, writing, maths) Social functioning