Block 2 Cartilage & Bone Flashcards
fundamental ct cell
fibroblasts
stuff secreted by ct
extracellular matrix
hydrated, amorphus material; looks smooth, homogeneous under the microscope; has no form; typically gel-like
ground substance
long unbranched polysaccharide of repeating disaccharide units one of which is an amino sugar; eg hyaluronic acid; can have up to 25,000 disaccharide units; very hydrophilic, combine with much H₂O
gags
composed of a linear protein core (produced in rough ER) to which a large number of glycosaminoglycans attach; thus they look like bristles on a brush or have christmas tree shape
PGs
fasten various components of the extracellular matrix to one another including collagen and transmembrane proteins of the cells synthesizing fibers
glycoproteins
three proteins of ground substance
gags, pgs, glycoproteins
fibers of extracellular matrix
collagen/elastic
blank types of collagen exist
15
chondrocytes are in cavities called blank
lacunae
cartilage has blank blood vessels
no
3 types of cartilage
hyaline, elastic, fibro
type 2 collagen
hyaline/elastic
type 1 collagen
fibrocartilage
types of growth of cartilage
appositional, interstitial
most common cartilage and is in nose, long bones, trachea, bronchi
hyaline
hyaline cartilage has a blank surface for joints and a high blank
smooth, high tensile strength
elastic cartilage is similar to hyaline cartilage but it has elastic fibers and includes a blank
perichondrium
external ear, epiglottis, external and internal auditory meatus has blank
elastic cartilage
elastic cartilage cells are blank than hyaline cells and has blank intercellular matrix
larger, less
fibrocartilage is blank due to large amounts of collagen
acidophilic
iv discs, tmj disc, menisci, pubic symphysis all have
fibrocartilage
matrix of bone is blank by calcium phosphate in the form of hydroxyapatite crystals
mineralized
bone has type blank collagen
1
osteocytes reside in blank
lacunae
bone formation steps
fibroblast, osteoprogenitor, osteoblast, osteocyte
osteoblasts becomes blank in its own secretion and turn into osteocytes
trapped
bone matrix that is not yet mineralized
osteoid
cluster of embryonic connective tissue cells (mesenchyme) secrete matrix →bone
intramembranous ossification
a hyaline cartilage model of the desired bone is first made and it is then stepwise replaced by cells secrete matrix →bone
endochondral ossification
multinucleated cells that destroy bone
osteoclasts
osteoclasts lie in depressions called blank
howships lacunae
bone is laid down in layers called blank
lamellae
first bone laid down; abundant osteocytes, irregular bundles of collagen, and is replaced by secondary bone
primary bone
bone that develops inner and outer tables (plates) of dense bone with intervening space (diploe) containing spicules of bone (spongy bone) and marrow in between the spicules
flat
external covering of bone
periosteum
entire inner cavity of a bone is lined by blank
endosteum
shaft of long bone
diaphysis
most spongy bone occurs at ends of long bone called blank
epiphysis at either end
spongy bone is aka
cancellous bone
dense bone is aka blank bone
compact
walls of bone is made of blank bone
compact
end of epiphysis that articulates is covered with blank
hyaline cartilage
this covers diaphysis
periosteum
periosteum has a fibrous layer and and inner cellular layer (endosteum) that has blank and blank cells
osteoprogenitor/osteoblasts
inserition of periosteum into bone fibers…
sharpeys
periosteum is a dense blank tissue
collagenous ct
holes of spongy bone can be filled by these
marrow, fat cells
4 layers of bone outer to inner
periosteum, outer circumferential lamellae, inner circumferential lamellae, interstitial lamellae
haversian canals contain blank
blood vessels
target looking rings of layers
osteons
interstitial lamellae simply separate blank
osteons/haversian canals
transverse canals that have blood vessel running through from one canal to another
volkmans canal
communication canals to share nourishment
canaliculi
collagen fibers of a given lamella run blank to each other but are blank to those of adjacent lamellae
parallel, perpendicular
compact bone mostly has blank
osteons
hyaline cartilage model of a given bone is first made by blank and blank growth… then chondrocytes in the center blank… and blank increase in size and calcifies
appositional, interstitial…hypertrophy… lacunae
a blank is when osteoblasts lay down bone on surface of cartilage model
bone collar
calcified cartilage cells die due to lack of diffused nutrients; empty lacunae become future blank cavity of bone
marrow
osteoclasts resorb calcified cartilage and bone complex which blank marrow cavity
enlarges
endochondral bone formation replaces all cartilage of the blank but not at the blank
diaphysis, epiphyseal plates
epiphyseal plates grow for this many years
18-20
zone of epiphyseal plate that is a mass of hyaline cartilage with no marked mitotic activity
reserve cartilage
zone of epiphyseal plate where chondrocytes are rapidly dividing, and there are isogenous cells parallel to direction of bone growth
proliferation
zone of epiphyseal plate where chondrocytes mature, hypertrophy and accumulate glycogen
maturation/hypertrophy
zone of epiphyseal plate where chondrocytes die and lacunae enlarge, cartilage matrix calcifies
calcification
zone of epiphyseal plate where osteoprogenitor cells migrate into area, osteoblasts deposit bone on cartilage matrix, and there is resorption by osteoclasts
ossification
as long as proliferation rate and resorption rate are equal, the bone grows in blank
length
primary center of ossification is in the blank
diaphysis
secondary centers of ossification are in the blank
epiphyses
eventually after bone growth, the diaphysis and epiphysis become blank
continuous
cartilage persists on the blank after total ossification
articular surface
order of zones of maturation
resting, proliferation, hypertrophy,calcification
immature bone has more blank than mature bone
osteocytes
immature bone has less organized blank than mature bone
collagen
appositional growth is growing blank
wider
interstitial growth is growing blank
longer