Bleeding tutorials Flashcards
1
Q
How is warfarin prothrombotic for the first 24 hours?
A
It inhibits protein C
2
Q
what is the common risk factor for DVT?
A
Factor v Leiden (Activated Protein C resistance)
3
Q
What does a thrombophilia screen consist of?
A
protein C - Factor V Leiden (if APCR positive)
protein S - prothrombin gene mutation
antithrombin
lupus anticoagulant - anticardiolipin antibodies
4
Q
how is protein c activated?
A
thrombin binds to thombomodulin on endothelial cell
5
Q
How does Protein C have an anticoagulant effect?
A
it deactivates V and VIII
6
Q
what anticoagulents are good for preganancy
A
heparin, not Warfarin
