Arterial thrombosis and anti-platelet drugs

Question 1

what is the mechanism of aspirin?

Answer 1

Aspirin blocks cox and stops the production of Thromboxane A2

Question 2

what is the mechanism of clopidogrel

Answer 2

ADP receptor antagonist

Question 3

what is the mechanism of dipyridamole?

Answer 3

Phosphodiesterase inhibitor -reduces production of cAMP which is a ‘second messenger’ in platelet activation

Question 4

how soon before an elective operation should anti platelets be stopped?

Answer 4

7 days