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Psych > Bipolar Pharm > Flashcards

Bipolar Pharm Flashcards

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1
Q

drugs that reduce activity of what neurotransmitters relieve mania?

A

dopamine or noepinephrine

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2
Q

drug class that exacerbates mania in bipolar disorder

A

SSRIs

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3
Q

Name the three mood stabilizing agents

A

Lithium. Valproate (Depakote). Carbamazepine (Tegretol)

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4
Q

Medication that significantly decreases the frequency and severity of both manic and depressive episodes in about 70% of patients

A

lithium

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5
Q

May decrease norepinephrine and dopamine turnover. May augment the synthesis of acetylcholine, by increasing cholamine uptake into nerve terminals

A

lithium

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6
Q

Adverse effects include: tremor, edema, weight gain, decreased thyroid fxn

A

lithium

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7
Q

Side effect profile less than that of Lithium. Quick onset. May increase dose more rapidly

A

Valproate (Depakote)

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8
Q

Labs to check with valproate (Depakote)

A

LFTs and platelets

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9
Q

Comparable efficacy to Lithium. therapeutic window is 3-14. SE includes Steven’s Johnsons

A

Carbamazapine (Tegretol)

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10
Q

Treats bipolar depression without triggering mania, hypomania, mixed states, or rapid cycling. It has not demonstrated efficacy in the treatment of acute mania.

A

Lamotrigine (Lamictal)

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11
Q

first-line treatment for acute depression in bipolar disorder as well as a maintenance therapy

A

lamotrigine (Lamictal)

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12
Q

Name the first Generation Antipsychotics (DOPAMINE ANTAGONISTS)

A

Haloperidol (Haldol) and Chlorpromazine (Thorazine)

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13
Q

Effective in the treatment of schizophrenia, especially the positive symptoms

A

Haloperidol (Haldol) and Chlorpromazine (Thorazine)

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14
Q

Adverse effects include: akathisia, rigidity, tremor, tardive dyskinesia, and neuroleptic malignant syndrome

A

1st gen antipsychotics-Haloperidol (Haldol) and Chlorpromazine (Thorazine)

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15
Q

occurs after long-term treatment with an antipsychotic medication. Sometimes, this condition may become permanent

A

tardive dyskinesia

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16
Q

movement disorders including any of a number of repetitive, involuntary, and purposeless body or facial movements

A

dyskinesia

17
Q

an extreme form of internal or external restlessness

A

akathisia

18
Q

a muscle tension disorder involving very strong muscle contractions

A

dystonia

19
Q

chiefly found in the reticular formation of the pons and medulla, and target neurons in the spinal cord involved in reflexes, locomotion, complex movements, and postural control

A

extrapyramidal tracts

20
Q

anticholinergic medication. helps to re-establish a normal balance between dopamine and acetylcholine

A

cogentin

21
Q

Interact with different subtypes of dopamine receptors than standard antipsychotics. Produce fewer neurological and endocrine side effects

A

Serotonin-Dopamine antagonists (Second Generation Antipsychotics; atypicals)

22
Q

Effective in treating negative symptoms (such as withdrawal) in addition to the positive symptoms.
Effective for a broader range of patients
Cause very few, if any, extrapyramidal side effects

A

Serotonin-Dopamine antagonists (Second Generation Antipsychotics; atypicals)

23
Q

Side effects of Serotonin-Dopamine antagonists (Second Generation Antipsychotics; atypicals)

A

weight gain, glucose intolerance, DM, hyperlipidemia

24
Q

Atypical antipsycotic with side effect of agranulocytosis

A

Clozapine (Clozaril)

25
Q

Atypical antipsycotic approved for treatment of a manic or mixed episode. also used for maintenance treatment after a severe or sudden episode

A

Aripiprazole (Abilify)

26
Q

Atypical antipsychotic associated with drowsiness

A

Quetiapine (Seroquel)

27
Q

1st line therapy for acute depression in patients with bipolar disorder

A

Lithium or Lamotrigin (Lamictal)

Psych (20 decks)

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