Biochem Flashcards
1
Q
1. Which of the following substances are the most reliable diagnostically and accessible analytically for biochemical analysis of cerebrospinal fluid? A. Lactate B. Glucose and protein C. Immunoglobulin D. Albumin E. Myelin Basic Protein (MBP)
A
B. Glucose and protein
2
Q
- Which one of the following conditions is not clinically informative in disorders of CSF and provides only confirmation of hyperglycemia?
A. Disorder in carrier-mediated transport of glucose, e.g. TB meningitis, sarcoidosis
B. Active metabolism of glucose by cells or organisms, e.g. acute purulent, amebic, and fungal meningitis
C. Increased CSF [glucose]
D. Increased metabolism of glucose by the CNS, e.g. CNS neoplasm
E. Normal CSF [glucose], e.g. viral meningitis
A
C. Increased CSF [glucose]
3
Q
- Which of the following statements is wrong related to CSF?
A. CSF is formed in the choroid plexus
B. It is essential for the physical protection of the CNS
C. CSF turnover is rapid, exchanging totally about four times daily
D. CSF proteins, mainly albumin, are derived about 20% from intrathecal synthesis E. CSF is formed by selective ultrafiltration and active secretion
A
D. CSF proteins, mainly albumin, are derived about 20% from intrathecal synthesis
4
Q
4. Which of the following diseases has normal protein content in cerebrospinal fluid? A. Viral meningitis B. Subarachnoid hemorrhage C. Bacterial meningitis D. Tuberculous meningitis E. Brain Tumor
A
A. Viral meningitis
5
Q
- Which of the following statements is wrong for multiple sclerosis?
A. It is a demyelinating disesase
B. Ethanolamine plasmalogen is lost from white matter of the central nervous system
C. Sphingolipids is lost from white matter of the central nervous system
D. The CSF shows decreased phospholipid levels
E.The CSF shows increased IgG levels
A
D. The CSF shows decreased phospholipid levels
6
Q
- Which one of the followings is a correct statement related to vitamin A toxicity?
A. Intracellular binding proteins have unlimited vitamin A binding capacity
B. Increased cerebrospinal fluid pressure adversely affects the central nervous system functions
C. Hepatomegaly is not exhibited
D. Hypocalcemia develops
E. Hypolipidemia occurs in liver
A
B. Increased cerebrospinal fluid pressure adversely affects the central nervous system functions
7
Q
7. Which substance is found in higher levels in CSF compared to blood? A. Chloride B. Calcium C. Potassium D. Sodium E. Magnesium
A
A. Chloride
8
Q
8. Which substance is found in lower levels in CSF compared to blood? A. Calcium B. Chloride C. Magnesium D. Sodium E. Potassium
A
C. Magnesium
9
Q
9. Which of the following conditions is indicated by increased IgG and normal albumin levels in CSF? A. acterial meningitis B. Multiple sclerosis (MS) C. Fungal meningitis D. Viral infection E. Brain Tumor
A
B. Multiple sclerosis (MS)
10
Q
- Which of the following conditions does not compromise the blood–brain barrier, resulting in increased CSF protein?
A. Multiple sclerosis
B. Viral meningitis C. Encephalitis
D. Increased intracranial pressure E. Hemorrhage
A
A. Multiple sclerosis
11
Q
- Which one of the followings is a nonessential amino acid that acts as the primary neurotransmitter of many inhibitory interneurons in the spinal cord and brainstem?
A. Norepinephrine B. Acetylcholine C. Glycine
D. Histidine
E. Tryptophan
A
C. Glycine
12
Q
- Which one of the followings does not reflect the major functions and/or utilization of cerebrospinal fluid as an evidence of the presence of disease?
A. Physical support of neural structures
B. Excretion and “sink” action
C. Intracerebral transport
D. Similar to a complete blood count, CSF analysis has high sensitivity and specificity E. Control of the chemical environment of the central nervous system
A
D. Similar to a complete blood count, CSF analysis has high sensitivity and specificity
