Biliary Tract Anatomy & Labs Flashcards

1
Q

The RT and LT hepatic ducts join to for the ______ ______ ______.

A

Common hepatic duct

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2
Q

The GB is located at the ______ end of the MLF.

A

inferior

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3
Q

The GB neck tapers to form the _____ ______ which joins with the ____ _____ _____ to form the _____ _____ _____.

A

cystic duct, common hepatic duct, common bile duct

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4
Q

The CHD is _____ the liver.

A

outside

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5
Q

The MPV, CHD, PHA form the ______ ______ at the _____ ______. Some refer to this as the mickely mouse sign.

A

portal triad, porta hepatis

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6
Q

In the portal triad, the CHD is _______ and to the ______ of the MPV and the PHA is ______ and to the ______ of the MPV.

A

anterior/right

anterior/left

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7
Q

T/F - The cystic duct is commonly visualized.

A

F - it is uncommon so we use the term “common duct” to refer to the extrahepatic ductal system

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8
Q

What forms the ampulla of Vater?

A

CBD and main pancreatic duct (Duct of Wirsung)

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9
Q

What is the valve of Heister’s and what is its function?

A

spiral fold in the GB which controls bile flow in the cystic duct

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10
Q

What is a Hartmann’s pouch?

A

abnormal sacculation (diverticulum) of the neck of the GB

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11
Q

What is a phrygian cap?

A

fold between the body and fundus of the GB

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12
Q

What is a junctional fold?

A

fold between the body and neck (infundibulum) of the GB

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13
Q

The CBD passes _______ to the first part of the duodenum and pancreatic head, joining the duct of Wirsung at the _____ ____ _____.

A

posterior, ampulla of Vater

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14
Q

The GB is divided into what 3 parts?

A

neck, body, fundus

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15
Q

Muscular valve that controls the flow of digestive juices (pancreatic, bile) through the ampulla of Vater into the second part of the duodenum.

A

Sphincter of Oddi

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16
Q

The ampulla of Vater empties though the _______ ______.

A

duodenal papilla

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17
Q

Normal GB wall thickness.

A

<3mm

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18
Q

Cholecystokinin

A

hormone released into the blood in response to ingestion of fatty foods, causing GB contraction

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19
Q

Reasons for performing a fatty meal test

A

equivocal bile duct dilation
abnormal labs (conjugated bilirubin, alkaline phosphatase)
if the duct increases in size, positive result
if the duct decreases in size or is unchanged, negative result

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20
Q

Where should the CHD be measured?

A

At the porta hepatis, outside the liver where the RHA courses between the MPV and CHD, lumen only

21
Q

The size of the extrahepatic bile duct is the most sensitive means of distinguishing _______ from ______ jaundice.

A

medical (pre-hepatic/hepatic)

surgical (post hepatic)

22
Q

Measurement criteria for CHD

A

Normal <5mm
Equivocal 6-7mm
Dilated >8mm (consider age and surgery)

23
Q

Upper normal value of the CHD in elderly patients

A

10mm

24
Q

The CHD diameter increases with age, _____ mm decade rule. So at age 60, _____ mm is normal and at age 80, ____mm is normal.

A

1mm
6mm
8mm

25
Q

Postcholecystectomy, the CHD acts like a reservoir for bile so it may normally increase in size up to ____mm

A

10mm

26
Q

What parts of the biliary tree dilate with a distal common bile duct obstruction?

A

entire system distends including the GB

27
Q

What parts of the biliary tree dilate with a common hepatic obstruction?

A

only the CHD and intrahepatic ducts will dilate

GB will be contracted

28
Q

What parts of the biliary tree dilate with an obstruction at the junction of the RT and LT hepatic ducts?

A

only the intrahepatic ducts, GB will be contracted

29
Q

Bilirubin

A

end product of hemoglobin breakdown

30
Q

Total bilirubin

A

conjugated + unconjugated

31
Q

Conjugation

A

process of removing protein (albumin) from unconjugated bilirubin, making it soluble

32
Q

______ is important for bilirubin disposal. It not only renders the pigment excretable by the liver, but also detoxifies the waste product.

A

conjugation

33
Q

Indirect hyperbilirubinemia

A

unconjugated

34
Q

direct hyperbilirubinemia

A

conjugated

35
Q

Unconjugated (indirect) hyperbilirubinemia results from (3)

A

impaired hepatic bilirubin uptake
increased bilirubin production
impaired conjugation of bilirubin

36
Q

Conjugated (direct) hyperbilirubinemia results from (1)

A

defective bile outflow

37
Q

The kidneys do not filter ______ bilirubin as they are bound to albumin.

A

unconjugated

38
Q

The presence of bilirubin in the urine indicates_______ hyperbilirubinemia.

A

conjugated, remember that the kidneys cannot filter unconjugated

39
Q

Unconjugated hyperbilirubinemia results from impaired hepatic bilirubin uptake due to (5)

A
CHF
liver varices
TIPS
Drugs
Contrast agents
40
Q

Unconjugated hyperbilirubinemia results from increased bilirubin production due to (2)

A

hemolysis - rupture or destruction of RBCs
or
ineffective erythropoiesis - production of RBCs

41
Q

Unconjugated hyperbilirubinemia results from impaired conjugation of bilirubin due to (2)

A
Gilbert syndrome (3-7% adult pop)
Crigler-Najjar Syndrome Type I and II (rare, only few 100 cases)
42
Q

2 autosomal recessive disorders of bile metabolism resulting in underactivity of the conjugating enzyme system due to lack of the enzyme uridine diphosphate glycosyl transferase. Leads to unconjugated hyperbilirubinemia.

A

Gilbert syndrome

Crigler-Najjar Syndrome Type I and II

43
Q

Defective bile outflow from a bile duct obstruction results in reflux of ______ into plasma and direct hyperbilirubinemia.

A

conjugates

44
Q

Conjugated hyperbilirubinemia results from defective bile outflow due to (4)

A

hepatitis
biliary obstruction
hepatic insult due to sepsis
cardiogenic shock

45
Q

High levels of ______ bilirubin may secondarily elevate the level of _____ bilirubin.

A

conjugated, unconjugated

46
Q

alkaline phosphatase

A

ALP

enzyme that is concentrated in the bile ducts and also found in bone, liver, and placenta

47
Q

_____ increases with bone growth (children) and pregnancy (liver, placenta)

A

ALP

48
Q

_____ increases in diseases that impair bile formation, specifically bile duct obstruction

A

ALP

49
Q

ALP increases with (11)

A
choledocholithiasis
pancreatic carcinoma
cholangiocarcinoma
cholangitis
Mirizzi syndrome
choledochal cyst (Caroli's disease)
GB carcinoma
primary sclerosing cholangitis
primary biliary cirrhosis
bone growth and diseases
pregnancy