Benzodiazepines Flashcards
1
Q
what is the mechanism of action of benzodiazepines?
A
enhance the effector of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by increasing the frequency of chloride channels
2
Q
how long should benzodiazepines be prescribed for?
A
2-4 weeks
3
Q
how should a patient be withdrawn from a benzodiazepine?
A
1/8th of the daily dose every fortnight
4
Q
what are the features of benzodiazepine withdrawal syndrome?
A
- insomnia
- irritability
- anxiety
- tremor
- loss of appetite
- tinnitus
- perspiration
- perceptual disturbances
- seizure
5
Q
frequently bend - during barbeque
A
increase frequency of chloride channels = benzodiazepine
increase duration of chloride channels = barbiturates
