Benzodiazepine-CNS Flashcards by Istiak Mahmud Siam | Brainscape

Q

Benzodiazepine Ultra short acting ?

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A

CloraZepate

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Q

Benzodiazepine short acting ?

A

TriAzolam
MidAzolam
OxaZepam

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Q

Long acting benzodiazepine ??

A

Diazepam
Flurazepam
Parazepam
Quazepam
Nitrazepam

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Q

Benzodiazepine intermediate acting ??

A

AlprAzolam
EstAzolam
Lorazepam
Temazepam

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Q

Major inhibutory Neurotransmitters in the CNS ?

A

GABA

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Q

GABA receptor which type of channel ??

A

Cl- ion channel

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Q

Structure of GABA receptor ??

A

Pentameric structure

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Q

Two binding site for GABA location ??

A

Between ALPHA – BETA

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Q

BZ binding site in GABA receptor ??

A

Between ALPHA–GAMA

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Q

Barbiturate binding site in GABA receptor >??

A

Between ALPHA – BETA
Different Site

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Q

Alpha-1 subunit binding drugs name ??

A

Zolpidem
2.Zaleplon
3.Eszopiclone

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Q

Which sedative-hyptonics has low affinity for GABA ??

A

BZ

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Q

Anticonvulsant use of BZ ??

A

Epilepsy / Status epilecticus
Seizure

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Q

Anesthesia use of BZ&raquo_space;??

A

Diazepam
Lorazepam
Midazolam

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Q

How to inc the affintiy ??

A

Baclofen

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Q

Effeccts of BZ on diff stages of NREM sleep ?

A

Stage-2 NREM duration inc
Stage-4 NREM duartion dec

NREM- Non Rapid Eye Movement

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Q

Sedation effects of BZ ??

A

dec anxiety
Euphoria
Loss of self control
Impaired judgment
Anterograde amnesia

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Q

Drugs that enhance GABAergic action ??

A

BZ
Barbiturates-Phenobarbitone
Valproate
Vigabatrin
GabaPentin

Q

Mechanism of BZ shortly ??

My own way _____———–

A

BZ binds with GABA-R
inc affinity of GABA-R to GABA
GABA binds with GABA-R
inc frequency of opening Cl- channel
inc influc of Cl- ions
Hyperpolarization
No Action Potential
No excitability
CNS depression / Sedation / Hypnosis

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Q

Metabolism of BZ ?? Location ??

A

Liver

Q

A

Q

A

Q

A