Basic mammalian Tissue Structure Flashcards

1
Q

Describe drug administration and absorption.

A
  • Drugs must enter/leave bloodstream
  • Drugs must penetrate tissues and distribute throughout
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2
Q

State the two types of cell ‘barriers’.

A

Composed of epithelium or endothelium
- external absorption barriers e.g. modified epithelium
- internal barrier e.g. blood - tissue barriers

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3
Q

State the 4 categories of tissue and the primitive layers (germ cell) they develop from.

A
  • Connective tissue (from Mesoderm)
  • Muscular tissue (from Mesoderm)
  • Nervous tissue (from Ectoderm)
  • Epithelium (mesoderm/ectoderm /endoderm)
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4
Q

What is epithelia?

A

Tissues that act as protective layers and/or secretory components of body organs and systems

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5
Q

State the common characteristics of epithelia that contribute to their functional capabilities.

A
  • Formed into tightly cohesive cellular sheets
  • Cover/line body surfaces e.g. alimentary canal and exocrine ducts
  • Distinguishing tissue of most organs
  • All the vital traffic of the body passes through the epithelial layer e.g. digested food, oxygen, secretions
    High capacity for regeneration e.g. wound healing, intestinal abrasion
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6
Q

Describe the epithelia attribute limited intracellular space.

A

– Specialised intracellular junctions to hold cells close together.
– Effective barrier and blocks infiltration of fluids between cells

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7
Q

Describe epithelia attribute single or multiple layers of cells.

A

– Where diffusion / filtration is important, epithelia is a single layer thick.
– Where protection from abrasion is required, epithelial is multicell thick

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8
Q

Describe epithelia attribute free apical surfaces.

A

– During development or at maturity.
– Where cells of an epithelium face internal lumens.

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9
Q

Describe epithelia attribute basement membrane.

A

– Attachment of epithelia to underlying connective tissue.

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10
Q

Describe the epithelia attribute mitotic capability

A
  • Enables repair and regeneration
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11
Q

Describe the two structural characteristics epithelia are described as.

A

Arrangement of cells in layers
– Simple epithelium
– Pseudostratified epithelium
– Stratified epithelium

Cell shape
– Squamous cells
– Cuboidal cells
– Columnar cells
– Transitional cells

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12
Q

Describe the different cell layers.

A
  • Simple epithelia – one cell thick
  • Stratified epithelia – many cells thick but only bottom layer in contact with basement membrane
  • Pseudostratified epithelia – appear more than one cell thick but all cells
    rest on basement membrane
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13
Q

Describe the different cell shape.

A
  • Squamous – flattened like paving stones
  • Columnar – taller than they are wide
  • Cuboidal – similar height depth and width
  • Transitional – layers which change their shape when they are stretched
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14
Q

Where are simple squamous cells found.

A

alveoli and capillaries of lungs

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15
Q

Where are simple cuboidal cells found.

A

Kidney tubule

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16
Q

Where are simple columnar cells found.

A

Small intestine

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17
Q

Where are transitional cells found.

A
  • Only in urinary tract
  • Stretches to accommodate fluid changes
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18
Q

Where is stratified squamous found?

A

Oesophagus

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19
Q

Where are keratinised stratified squamous?

A
  • Only found in skin
20
Q

Where are pseudo stratified layers found?

A

Trachea, nasal mucosa

21
Q

Where are stratified cuboidal cell layers found?

A

Sweat gland duct

22
Q

Describe simple squamous cells.

A
  • lines blood vessels and air sacs of lungs
  • permits exchange of nutrients, wastes and gases
23
Q

Describe stratified squamous.

A
  • Outer layer of skin, mouth, vagina
  • Protects against abrasion, drying out, infection
24
Q

Describe simple cuboidal cells.

A
  • Lines kidney tubules and glands
  • Secretes and reabsorbs water and small molecules
25
Q

Describe stratified cuboidal cells.

A
  • Lines ducts of sweat glands
  • Secretes water and ions
26
Q

Describe the simple columnar cells.

A
  • Lines most digestive organs
  • Absorbs nutrients, produces mucus
27
Q

Describe stratified columnar.

A
  • Lines epididymus mammary glands, larynx
  • Secretes mucus
28
Q

Describe modifications of the basal surface.

A
  • Basement membrane = basal lamina (selectively permeable filter)
29
Q

Describe modifications of the apical surface.

A
  • Microvilli - finger-like extensions of the plasma membrane and increase surface area for absorption’s e.g. small intestine
  • Cilia - whip-like, motile extensions, moves mucus etc over epithelial surface in one direction e.g. trachea and respiratory bronchus
30
Q

Describe modifications of the lateral surface.

A
  • Adhesion Junctions - adhesive spots (Desmosomes) on lateral sides, involves cadherin proteins
  • Tight Junctions – apical plasma membrane of adjacent cells fuse - Nothing passes. e.g. GI tract (prevents enzymes entering bloodstream)
  • Gap Junctions - Spot-like junctions allowing small molecule passage
31
Q

Describe the glandular epithelium.

A

Aggregates of epithelial cells clustered together to perform specific secretory or excretory function

32
Q

What products do glandular epithelium secrete?

A

– Hormones
– Enzymes
– Milk
– Sweat
– Mucous
– Oil

33
Q

State the glandular classifications.

A
  • EXOCRINE
    – Pour products into ducts that open into lumen of organ or
    onto the skin
  • ENDOCRINE
    – Have no duct system – ductless glands – secrete into empty
    tissues spaces – eventually enter blood stream
34
Q

Describe the morphological classifications of exocrine glands.

A

Simple – single tube
Compound – branched duct system

Secretory
- Tubular
- Acinar/Alveolar (grape like)
- Saccular (pouch like)

35
Q

Describe the secretory mechanism merocrine

A

– e.g. salivary gland - secretion passes from cells without
damage to plasma membrane – exocytosis
– Most glands secrete in this way

36
Q

Describe the secretory mechanism holocrine.

A

– e.g. sebaceous gland –cellular debris part of secretion (sebum)
– involves death of the cell

37
Q

Describe the secretory mechanism apocrine

A

– e.g. mammary gland –
– apical end pinched off

38
Q

Define membranes.

A

Thin sheets of flexible tissue that line or cover parts of the body

39
Q

Describe serous membranes.

A
  • Line closed body cavities, secrete a watery serous fluid
  • Simple squamous (generally),resting on thin layer connective tissue
  • Parietal layer attaches to the body wall around the organ
  • Visceral layer attaches to the organs themselves
40
Q

Describe mucous membranes.

A
  • Line cavities open to outside
  • Mucous cells / glands lumen of digestive(microvilli), reproductive,
    respiratory tracts (ciliated)
  • Epithelial cells vary in morphology & function
41
Q

Describe cutaneous membranes.

A

Cutaneous membrane is the skin, covering the outer surface of the body
– Keratinised squamous epithelium

42
Q

Describe synovial membranes.

A

Synovial membranes line cavities of freely movable joints,
– Incomplete epithelium
– Contain connective tissues

43
Q

Describe epithelial absorptions barriers.

A

– Cells connected via tight junctions to create an unbroken epithelium
– Drugs MUST cross the liphophilic epithelial plasma membrane to
enter the body (except parenteral)

44
Q

Describe blood-tissue barriers.

A

– Endothelial cells connected into continuous barrier via tight junctions
– Differences in capillary beds between tissues

45
Q

Describe membrane permeation.

A

– Passive diffusion – compounds high lipid solubility, dependency on
drug charge and pH
– Active Transport – Drugs ‘hijack’ cellular transporters
– Receptor Mediated Endocytosis – Endosomal vesicles, then recycled
to cell surface