Bacterial Physiology And Pathogenesis (Lec) Flashcards
The ability of bacteria/pathogens to harm the host
VIRULENCE
process on how they cause the disease
MICROBIAL PATHOGENESIS
- loose network of polymers extending outward from the cell
- adds protection to the cell
- e. coli, streptococcus
SLIME LAYER
- similar to slime layer but slime layer can be washed easily
- extracellular structure that protects bacteria
CAPSULE
used for attachments
FIMBRIAE
use for genetic exchange
PILI
It causes abortion in cattles
Brucella abortus
It is a nutrient in all living organisms. For humans, it’s growth limiting micronutrient
Iron
- help bacteria get iron
- catches iron in the body
- get iron from transferrin and lactoferrin
SIDEROPHORE
bacteria in bloodstream
bacteremia
spread of pathogen, massive inflammation -> septic shock -> death
septicemia
infection that affects the entire body, rather than a single organ or body part.
systemic infection
the ability of a pathogen to enter the host cells
INVASION
ability to cause disease, to produce toxin material
TOXICITY
comes from: kalawang, soil
clostridium tetani = tetanus
- promotes spreading of organisms in tissues
- hyaluronic acid tightens face
- bacteria prevents hyaluronic acid
- s. aureus common cause of pimples
- k-toxin heals tissue
streptococcus, staphylococcus and certain clostridium = hyaluronidase
- Insoluble blood protein
- forms blood clots
FIBRIN
dissolves fibrin
streptokinase
forms fibrin clots
coagulase
- produced inside the cell but goes outside
- are toxic proteins released from the pathogen cell as it grows
- cytolytic, AB toxin, super antigen
EXOTOXIN
- acts on the intestinal wall
- Causes diarrhea
ENTEROTOXIN
- toxin that disrupts nerve cells
- Clostridium tetani
- Clostridium botulinum (bones)
NEUROTOXIN
- soluble, extracellular proteins produced by a variety of pathogens
- damage the host cytoplasmic membrane, causing cell lysis and death
- toxin that attacks the cell
CYTOLYTIC TOXIN
- inhibit protein synthesis
- produces a and b toxin
- improperly preserved foods
- respiratory failure due to flaccid muscle paralysis
AB TOXIN
- body produce cytokins to kill s. aureus
- large quantities of cytokin cause inflammation –> septic shock
SUPERANTIGEN
- inside
- LPS
- e.coli, shigella & salmonella
- less toxic than exotoxin
ENDOTOXIN
- to detect LPS
- uses horseshoe blood
LAL (Limulus amoebocyte lysate)
It is used in the biomedical industry to test medical devices and parenteral drugs for bacterial contamination before they are distributed
LAL (Limulus amoebocyte lysate)
LPS consists of three covalently linked subunits:
membrane-distal O-polysaccharide, lipid A, and a membrane-proximal core polysaccharide
