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IBI Test 3 > B3.044 - Evidence Based Medicine: Evaluating New Drugs > Flashcards

B3.044 - Evidence Based Medicine: Evaluating New Drugs Flashcards

1
Q

heparin and warfarin are both used for what

A

to treat venous thrombi

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2
Q

which drug is used first for venous thrombi

A

heparin

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3
Q

warfarin is used to prevent blood clots in patients with what

A

atrial fribrillation

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4
Q

what is the goal of warfarin

A

prolonged PT

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5
Q

when is the therapeutic goal of warfarin achieved

A

about 1 week

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6
Q

which drug has a slow onset

A

warfarin

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7
Q

what is the INR

A

the international normalized ratio of test/control

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8
Q

why is warfarin dose selection so difficult

A

narrow therapeutic index

multiple factors affect pharmacokinetics and pharmacodynamics

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9
Q

what are the big dietary things that affect warfarin function

A

alcohol and leafy greens

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10
Q

why is an alternative to warfarin something we want

A

bad side effects and interactions

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11
Q

what is alpha

A

probability of a false positive

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12
Q

what is beta

A

probability of a false negative

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13
Q

what is beta usually

A

.2

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14
Q

what is alpha usually

A

.05

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15
Q

what is a type 1 error

A

rejecting null when you shouldnt have

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16
Q

what is a type 2 error

A

not rejecting null when you should have

17
Q

how is power calculated

A

1-beta

18
Q

steps to calculating sample size (4)

A
  1. determine study size, measure of frequency, measure of effect, stat method
  2. set acceptable levels of risk of a type 1 and type 2
  3. determine magnitude of diff in outcomes between 2 groups
  4. calculate sample size requirement
19
Q

larger differences require what to be detected

A

smaller sample sizes to be detected

20
Q

reduced risk of type 1 error results in

A

larger sample size requirement

21
Q

reduced power results in

A

smaller sample size requirement

IBI Test 3 (16 decks)

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