B3.038 - Hematopoeisis Flashcards

1
Q

What acts on pluripotent stem cells?

A

SCF, IL-6, Flt3L

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2
Q

What acts on lymphoid stem cells

A

SCF, Ftl3L, IL-7

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3
Q

What acts on trilineage myeloid stem cells

A

IL-3, IL-6, GM-CSF

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4
Q

What is extra medullary hematopoeisis

A

Reactivation of hematopoeisis outside bone marrow due to insufficient bone marrow reserve

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5
Q

What are sites of extramedullary hematopoeisis

A

Lymph, liver, spleen, soft tissue

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6
Q

What are neutrophils

A

Phagocytes, segmented nucleus

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7
Q

What are examples of primary granules

A
Myeloperoxidase
Lysozyme 
Defensins 
Acid hydrolases 
Neutral Proteases
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8
Q

What are examples of secondary granules in cytoplasm of neutrophils

A
Lysozyme 
Collagenase 
Lactoferrin 
Plasminogen activator 
Histamine
Alkaline phostphatase
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