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ABC > Autoimmunitetsdiagnostik inom klinisk immunologi > Flashcards

Autoimmunitetsdiagnostik inom klinisk immunologi Flashcards

1
Q

Vilka autoantikroppar mäts för Reumatoid artrit (RA)?

A
  1. Reumatoid faktor (RF) - AK mot Fc-del av IgG 2. ACPA = anti-CCP - Har högre specificitet än RF - Första hands val.
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2
Q

Vilken Ig är associerad med RF?

A

IgM/IgG/IgA RF

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3
Q

Vad är The shared epitope hypothesis?

A

RA associerat med flera olika HLA-alleler med samma aminosyror i en viktig region av HLA- molekylen

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4
Q

ANA-undersökning består två delar: vilka?

A
  1. Fluorescensmönster (mikroskopi) 2. Eventuell påvisad bakomliggande antikropp
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5
Q

ANA: grundmönster

A
  1. Homogen 2 Kornig 3 Anti-centromerantikroppar 4. Anti-nukleolära antikroppar 5. (anti-cytoplasmatiska antikroppar)
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6
Q

Vad visar bilden?

A

Homogen ANA

Mot DNA/DNA-
proteinkomplex

Anti-DNA

Anti-histon

Anti-topoisomeras 1

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7
Q

Vad visar bilden?

A

Kornig ANA

Mot RNP/RNA-proteinkomplex

Mot 4 antikroppar

  1. Anti-SSA
  2. Anti-SSB
  3. Anti-RNP -
  4. Anti-Sm
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8
Q

Vad visar bilden

A

Anti-centromerantikroppar

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9
Q

Vad visar bilden?

A

Anti-nukleolära antikroppar

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10
Q

Nämn två sjukdomar associerad med Anti-SSA/Ro60 (syns på bilden)

A
  1. SLE
  2. Sjögrens syndrom
  3. Fotosensitivitet
  4. Kutan lupus
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11
Q

Klinisk triad för fosfolipidantikroppssyndrom

A

Upprepade tromboser

Trombocytopeni

Upprepade missfall

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12
Q

“Anti-fosfolipidantikroppar” tre tester:

A
  1. anti-kardiolipin (IgG+IgM)
  2. anti-ß2 glykoprotein-1 (IgG+IgM)
  3. lupus antikoagulans (funktionstest
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13
Q

Skillnad mellan direkt och indirekt immunfluorescens:

A

Direkt: antikroppar i vävnadsbiopsier

Indirekt: undersökning av antikroppar i serum

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14
Q

Vad är bullös pemfigoid?

A

Antikroppar mot
hudens basalmembran

(indirekt immunfluorescens)

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15
Q

Vad är pemfigus vulgaris?

A

Antikroppar mot hudens intercellulärsubstans

(direkt eller indirekt immunfluorescens)

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