Autoimmune Liver Disease

Question 1

What are the three types of antibodies in autoimmune hepatitis

Answer 1

Type 1: ANA, SMA
Type 2: LKM1
Type 3: SLA

Elevated IgG also often found

Question 2

How is AH diagnosed

Answer 2

Checking for 3 antibodies AND liver biopsy

Question 3

Treatment

Answer 3

Steroids

Azathioprine

Question 4

Which antibody is elevated in primary biliary cholangitis

Answer 4

IgM

Question 5

Diagnosis of PBC

Answer 5

test positive for anti-mitochondrial antibody

Question 6

What is the cause of symptoms in PBC

Answer 6

The intrahepatic bile duct is inflamed and blocked

Question 7

Common symptoms of PBC

Answer 7

Pruitis and fatigue

Question 8

PBC treatment

Answer 8

Ursodeoxycholic acid (UDCA)

• flushes bile salts out of the liver

Question 9

What is primary sclerosing cholangitis

Answer 9

Stricturing disease involving both intra and extra-hepatic bile ducts

Question 10

Which antibody is positive in PSC

Answer 10

pANCA

Question 11

What is the test of choice in PSC

Answer 11

MRCP

Question 12

What does PSC cause

Answer 12

recurrent cholangitis and jaundice

Question 13

PSC treatment

Answer 13

Liver transplant and biliary stent

Question 14

Out of AH, PBC and PSC, which of the 3 is predominantly found in males

Answer 14

Primary sclerosing cholangitis