Atypical Antipsychotics

Question 1

second generation antipsychotic names

Answer 1

quetiapine, olanzapine, risperidone, aripiprazole (Quiet please, Only Whispering is Appropriate), ziprasidone (zipper), clozapine (closet)

Question 2

how SGAs work

Answer 2

some blocking of D2 receptors in the CNS, but mostly blocking serotonin receptors (5HT2A)

Question 3

what SGAs treat

Answer 3

treat positive and negative symptoms of schizophrenia (mustache blocking both ears)
treats treatment resistant depression (resistant happy and sad masked wine bottle)
manage OCD with SSRIs (person fixing the painting)
tourette syndrome - only risperidone (marionette)

Question 4

SGA side effects

Answer 4

block H1 histamine receptors = sedation (bee swatter)
block alpha-1 receptors = orthostatic hypotension (a candle)
block muscarinic receptors = dry mouth, constipation, blurry vision, urinary retention (mostly clozapine - atropine in wonderland behind the closet)
weight gain, dyslipidemia, and hyperglycemia (olanzapine and clozapine - fat face with butter and candy)
torsades de pointes

Question 5

clozapine specific side effects

Answer 5

agranulocytosis (melting snad timer)
myocarditis and cardiomyopathy (surreal heart)
lower seizure threshold (shaking clock)

Question 6

which SGA has the highest likelihood of EPSEs

Answer 6

risperidone (whispering man to the guy with the extra pyramid hat)