Arterial Blood Gas

Question 1

What variables stabilize the T form of hemoglobin?

reduced oxygen affinity

Answer 1

Low pH
2,3 BPG binding
Higher CO2

Question 2

What variables stabilize the R form? increased oxygen affinity

Answer 2

Higher pH
no 2,3 BPG binding
Lower CO2

Question 3

What are the 3 forms of CO2 in the blood?

Answer 3

• Dissolved CO2
• Attached to Hemoglobin as N-terminal Carbamates
• Bicarbonate Ion 80-90%

Question 4

What is the Haldane effect?

Answer 4

The CO2 concentration of blood differs as a function of blood oxygenation

• Less CO2 in oxygenated blood
• more CO2 in deoxygenated blood

Question 5

What are the H-H equation values for the Bicarbonate buffer system?

Answer 5

pH = 6.1 + 
log([HCO3-]/(0.03)PCO2) = 7.4

Question 6

How does the respiratory system adjust systemic pH?

Answer 6

It will increase or decrease RR to regulate pCO2.

FAST (hours)

Question 7

How do the kidneys adjust systemic pH?

Answer 7

Kidneys add or decrease Bicarbonate and H+ excretion to increase or decrease pH.
SLOW (days)

Question 8

What is normal physiologic pH?

Answer 8

about 7.4

Question 9

What are the lab findings in Metabolic Alkalosis?

Answer 9

pH >7.4

HCO3 > 24 (High Bicarbonate)

Question 10

What are the lab findings in Respiratory Alkalosis?

Answer 10

pH >7.4

HCO3 less than 24 (Low Bicarbonate)

Question 11

What are the lab findings in Metabolic Acidosis?

Answer 11

pH

Question 12

What are the lab findings in RespiratoryAcidosis?

Answer 12

pH