Aquaporins

Question 1

NMO

Answer 1

Neuromyelitis Optic is an autoimmune disease induced by a specific auto-antibody, the NMO IgG.

NMO Ab affects the optic nerve and spinal cord by targeting Aquaporin 4. Aquaporin 4 has very high concentrations around ventricles to make CSF. Results in complement activation.

Female: Male = 9:1

Question 2

Another name for NMO

Answer 2

Devic disease

Question 3

Specific biomarker for NMO

Answer 3

NMO IgG

Question 4

Where is CSF produced

Answer 4

Produced by the chorioid plexus of each ventricle. (epithelial derrived)

Question 5

Flow pathway of CSF

Answer 5

Travels through the ventricles and into the subarachnoid space via the medial and lateral apertures. Some CSF travels through the central canal of the spinal cord. It flows through the subarachnoid space and absorbed into the dural cavity.

Question 6

How does restasis work?

Answer 6

Targets aquaporins to increase tear production.