Antivirals

Question 1

Neuraminidase inhibitors

Answer 1

Zanamivir, oseltamivir, peramivir

“AMIVIR”

Question 2

Zanamivir

Answer 2

AE
-Cough
-Headache

Cl
-Milk protein hypersensitivity
-CPD
-Asthma

zana eats CCHAM for lunch

Question 3

Oseltamivir

Answer 3

AE
-Headache
-NV

OS and ViNH

Question 4

Peramivir

Answer 4

AE
-Diarrhea

Question 5

Amautadine

Answer 5

MOA: interferes with M2 protein, block ribo-protein complex

AE:
-CNS (ins/nerv/light head)
-GI

AM going to the Vegas GMC

Question 6

NRTIs and Class AE
Nucleoside Reverse Transcriptase Inhibitor

Answer 6

Didanosine
Zidovudine
Lamivudine
Abacavir
Tenofovir
Emtricitabine

“DINE” “BINE” just vir PLAN for flight Z DELTA

Class AE:
-Pancreatitis
-Lacticacidosis
-Anemia
-Neuropathy peripheral

Question 7

Abacavir AE

Answer 7

Hypersensitivity reactions (BBW), HLA 135701 test before starting
-Rash, fever, fatigue

ABA is SENSITIVE

Question 8

Tenofovir AE

Answer 8

Renal / bone toxicity
-Dose adjustment for renal dysfunction

TENO likes RBs (arbys)

Question 9

Zidovudine AE

Answer 9

-Lipoatrophy
-Hepatoxicity or Lactic acidosis

ZID is going to HALL

Question 10

Have activity for HepB

Answer 10

Lamivudine

Tenofovir

Emtricitabine

LET
-BBW for HepB exacerbation

Question 11

Didanosine AE

Answer 11

-Pancreatitis
-Hepatotoxicity or Lacticacidosis

DID you ask for HALP

Question 12

NNRTIs
-Non Nucleoside reverse transcriptase inhibitor

Answer 12

Efavirenz
Nevirapine
Etravirine
Rilpivirine

VIR in middle RENE is in CHRge of the middle

Class AE
-Rash
-Hepatotoxic (increase LFT)

DI: CYP (not RIL)

Question 13

Food vs Without Food: NNRTI

Answer 13

Efavirenz - EMPTY STOMACH

Nevirapine - Doesn’t Matter

Etravirine - FOOD

Rilpivirine - FOOD

Question 14

Efavirenz AE

Answer 14

-CNS symptoms (vivid nightmares, stoned)
-Teratogenic

that hEFA has the Tea on CVS

Question 15

INSTIs

Answer 15

Raltegravir
Elvitegravir
Dolutegravir
Bictegravir

I INSIST you B REDy for TEGRA G

Class AE
-GI

Question 16

Elvitegravir

Answer 16

Metabolized via 3A4, use with BOOSTER (cobicistat)

Question 17

PIs and Class AE

Answer 17

Atazanavir
Darunavir
Ritonavir (ONLY booster)
Neflinavir
Indinavir

NAVIR: block cleave of protein precursors

ADRIN and NAVIR are PIs who eat CHuM

AE:
-Metabolic (HYPER lipid/glyc, fat redistribution)
-Hepatotoxicity (increase LFT)

DI: CYP

Question 18

Atazanavir AE

Answer 18

Hyperbilirubinemia

ATAZ is dating BILLY

Question 19

Only Pl that does not require boosting

Answer 19

Neflinavir

Question 20

Tx in HIV

Answer 20

2 NRTI and 1 INSTI (most pt)

Treatment naive pts
= 2 NRTIs and a 3rd drug

Question 21

HIV LABS

Answer 21

-CD4 T cell count (UP)
-HIV RNA (viral load) (DOWN)

Question 22

Maraviroc

Answer 22

MOA: CCR5 antagonist, blocks viral entry

MUST do tropism test before

AE: increase risk of infections

DDI: 3A4 inhibitors/inducers

MARA wants a TIE (backwards 3) and a CR5

Question 23

Enfurirtide

Answer 23

MOA: binds to gp41, blocks viral entry

AE: Injection site rxn

FURry gets injected with GP41

Question 24

Ibalizumab

Answer 24

MOA: mab against CD4, block HIV entry

USE: HIV with MDR

AE: diarrhea, dizzy
-Immune reconstitution inflammatory syndrome

IRIS wants to go to BALIZ so she DID in CD4 M(mdr)onths

Question 25

Coronavirus TX

Answer 25

-IV fluids
-Tylenol

-Remdesivir
MOA: inhibitor of RNA polymerase
AE: increase liver enzymes, infusion rxns

RIRI of the covid drugs

Question 26

Nirmatrelvir and ritonavir (paxlovid)

Answer 26

MOA: protease inhibitor, decrease viral rep. + booster

Efficacy: 89%

> 12 yo and high risk of severe COVID

AE: diarrhea, dysgeusia (task disturbance)

Question 27

If nirmatrelvir ritonavir and remdesivir not available for COVID:

Answer 27

Molnupiravir

MOA: creates errors in viral genome, inhibit rep.

AE: dizzy, diarrhea