Antibiotics: DNA

Question 1

Sulfonamides: Sulfamethoxazole (SMX)
+ Trimethoprim (TMP)

Answer 1

MOA:
1. inhibit folic acid synthesis
2. inhibit DHFR

USE: broad spec

AE:
-Hypersensitivity (SJS)
-GI (NVD)
-Heme
-HYPERKALEMIA

DDI:
-ACEI/Ami/Spironolactone/Warfarin

CI:
-Pregnancy, Children

CP WAAS FAD HHHG

Question 2

Fluoroquinolones: “floxacins”

Answer 2

MOA: inhibition of topoisomerase II

USE: HNPEK, CAPES, Gram pos

AE:
-GI (NVD)
-Neurotoxicity (diz/in/seizure/neuropathy)
-Derma (photo/rash)
-Musculoskeletal (tendons)
-Cardiac: QTP

CI: Pregnancy, Children, Tendonitis

DI: Cations Multivalent (2 hr B4 / 4 hr AF)

Flowers go to MD GNC is at the TOP (TCP)

Question 3

Metronidazole

Answer 3

MOA: ferredoxin = generation of free radicals = DNA damage = bacterial cell death

USE: Gram + and - anaerobes

AE:
-GI (NVD, metallic taste, furry tongue)
-Disulfiram rxn with alcohol
-CNS (neuropathy)

CI:
-Pregnancy
-New primary malignancy
-Seizures
-Alcoholism

FE(E) to take NAPS on the DCG metro

Question 4

Rifampin

Answer 4

MOA: inhibition of RNA synthesis

USE: TB, influenza pro, men pro

AE:
-Hepatoxicity
-Red/orange body fluids

DI: CYP

RIF is a HOR