Antiparasitic 2

Question 1

Metronidazole

Answer 1

MOA: gen. of free radicals, disrupt DNA, cell death

USE: amebiasis, “iasis”

Question 2

Tinidazole

Answer 2

MOA: gen. of free radicals, disrupt DNA, cell death

USE: amebiasis, “iasis”

Question 3

Paromomycin (aminoglycoside antibiotic)

Answer 3

MOA: 30S subunit, interfere with initiation
complex, inhibition of protein synthesis

USE: amebiasis, giardiasis

AE: GI, rash

MOM is 30 GIR

Question 4

Iodoquinol

Answer 4

Unknown MOA

USE: amebiasis

AE:
-GI (diarrhea)
-Enlarged thyroid

IODO GIT

Question 5

Nitazoxanide

Answer 5

Unknown MOA

USE: giardiasis

AE:
-Abdominal pain
-Diarrhea

NITALIE IS GAD

Question 6

Albendazole

Answer 6

MOA: interferes with microtubule synthesis

USE: GI nematodes, cysticerosis

AE: GI effects

CI: pregnancy, hepatic disease

Question 7

Pyrantel pamoate

Answer 7

MOA: NM block, paralysis of the worm

USE: intestinal helminths (worms)

AE:
-GI
-Dizzy
-Elevation of liver enzymes

WN got his GED

Question 8

Ivermectin

Answer 8

MOA: GABA agonist (Cl ch)

USE: intestinal nematodes (not hookworm)

AE:
-GI (dia)
-Derm (pruritis)

CI: pregnancy

Question 9

Praziquantel

Answer 9

MOA: increase membrane permeability to Ca

USE: schistosomiasis, intestinal tapeworms

AE:
-GI (NVD)
-CNS (HA/diz)
-Pruritus