Antibiotics: Protein

Question 1

Aminoglycosides
– Gentamicin – Tobramycin – Amikacin

Answer 1

MOA: binding to phosphates in LPS = “cracks” membranes = membrane damage

USE: Gram neg aerobes

SYNERGISM with cell wall inhibitors!

AE:
-Nephrotoxic
-Ototoxic
-Respiratory paralysis

CI:
-Renal disease
-Hearing impairment
-Pregnancy

OH PP NN RR

Question 2

Oxazolidinones
– Linezolid
– Tedizolid

Answer 2

MOA: Inhibits the formation of the initiation complex on 50S

USE: gram-positive mainly

AE:
-GI distress
-Bone marrow suppression (TCP)
-Optic/peripheral neuropathy

DI: MAOI/SSRI = serotonin syndrome
-HTN crisis if with tyramine foods

ZOLA is POS that MS GOB is 50

Question 3

Tetracyclines
– Doxycycline – Tetracycline – Minocycline – Tigecycline

Answer 3

MOA: bind to 30S subunit and inhibit aminoacyl tRNA binding

USE: broad spec

AE:
-GI
-Bone/teeth
-Phototoxicity

DI: Cations (antacids/Ca/Mg/Fe)

CI: Children / Pregnancy

CPC is 30 and eats PBG on HER BICYCLE

Question 4

Macrolides
– Azithromycin – Erythromycin – Clarithromycin

Answer 4

MOA: bind to 50S subunit, inhibit Peptidyl-tRNA

USE: broad spec

AE:
-GI
-Hepatoxicity
-Cardiac: QTP

DI: CYP / PGP

Mac is on CH G50

Question 5

Clindamycin

Answer 5

MOA: bind to 50S subunit, inhibit Peptidyl-tRNA

USE: Gram + / Anaerobes

AE:
-GI (NVD)
-C diff