Antiparasitic

Question 1

Malaria SX

Answer 1

Abrupt onset of coldness and chills, followed by high fever, headache, nausea and vomiting

Female mosquito (Anopheles)

Question 2

Quinine and quinidine

Answer 2

MOA: blocks heme to hemozoin

USE: malaria

AE:
-GI
-Cardiac: QTP-TdP
-Cinchonism (tinnitus/dis. vis./HA/diz)
-Heme (anemia hemolytic)

CI: G6PD deficiency (quinine only)

DI: CYP / PGP

QQ HH CC GG

Question 3

Chloroquine and hydroxychloroquine

Answer 3

MOA: Inhibits hem-polymerase activity (toxic build up of heme)

USE: malaria

AE:
-GI
-Cardiac: QTP
-Pruritus
-Visual disturbances

CI: Psoriasis, Ocular disease

SAFE IN PREGNANCY

covid drug so : C PP in the GOV

Question 4

Mefloquine

Answer 4

MOA: Inhibits hem-polymerase activity

USE: malaria

AE:
-GI
-Cardiac: QTP
-CNS (vivid dreams, HA, anxiety, seizure, psychosis)

CI: epilepsy/psychosis/dep/anx/schizo

Mef is GCCC

Question 5

Primaquine

Answer 5

Unknown MOA

USE: malaria

AE:
-GI
-Cardiac: QTP
-Heme (must test for G6PD), look for dark/blood urine

CI: G6PD, Pregnancy

DI: Warfarin

Question 6

Artesunate, artemether, dihydroartemisinin

Answer 6

MOA: bind iron, break down peroxide bridges, free radicals, damage parasite

USE: malaria

AE:
-GI (NVD)
-CNS (diz)

CI:
-First trimester of pregnancy
-Children under 5kg

ART wants 15 GCs of iron

Question 7

Atovaquone and proguanil

Answer 7

MOA: disrupt nucleotide synthesis and DHFR inhibitor

AE:
-GI (abd pain, NVD)
-Elevation of liver enzymes

CI: Pregnancy

ATOV said GEP!

Question 8

Tetracycline, doxycycline and clindamycin

Answer 8

MOA: Inhibition of protein synthesis in parasite apicoplast

USE: chemoprophylaxis, combo for malaria