Antifungals

Question 1

Polygenes - Amphotericin B

Answer 1

MOA: poke holes in fungi

USE: BS, DOC

AE:
-Infusion related rxn
-Nephrotoxic
-HYPO K/Mg

amphrodite Loses (take L) and just gets a PIN

Question 2

5 flucytosine

Answer 2

MOA: deaminated by cytosine to break cell well (xDNA/RNA)

AE:
-Hematologic toxicity (an/leuko/thrombo)

Question 3

“AZOLES”

Answer 3

MOA: block lanosterol to ergosterol

AE:
-NV
-Hepatoxic

DI:
-CYP

Azole go sit on the VENCH

Question 4

Fluconazole AE

Answer 4

GI, chapped lips

Question 5

Voriconazole AE

Answer 5

Visual disturbances

Question 6

Echinocandins (micaungin, caspotungin, anidulafungin)

Answer 6

MOA: inhibit beta glucan synthase

AE: minor
-Some histamine release (HA, flush, pruritus, urticaria)

HIS ungin is gross

Question 7

Terbinafine

Answer 7

MOA: inhibits squalled-epox

USE: derm infections (nails)

AE:
-Taste disturbance
-GI
-Hepatoxic
-HA

THHaG you’re it Terb!

Question 8

“AZOLES” USES

Answer 8

FLU: C and G

VORI: C and G and A

POSA: C G A M

FVP like mvp, each level add letter, CG +A +M

Question 9

Micafungin USES

Answer 9

A and C

MAC

Question 10

Amphoterician USES

Answer 10

ALL: C G A M

amphrodite has it ALL

Question 11

5 FC USES

Answer 11

JUST C