Anticoagulants Flashcards
Aspirin
MOA: inhibits COX1, decrease platelet aggregation (anti-platelet)
AE:
-GI (ulcer, abd. pain, nausea)
-Bleeding
Clopidogrel, Prasugrel, Ticagrelor, Cangrelor
ABC
MOA: blocks ADP receptors
AE: Bleeding
DI:
-Clopidogrel and prasugrel = Drugs that interfere with CYPs
Abciximab, Eptifibatide, Tirofiban
MOA: gpIIb/IIIa R antagonists, decrease platelet aggregation
AE:
-Bleeding
-Thrombocytopenia (abciximab)
Warfarin
MOA: inhibits vitamin K epoxide reductase (VKOR)
AE:
-Bleeding
-Skin necrosis
DI:
-Vitamin K
-Induce/inhibit CYP2C9 or compete with warfarin
Warfarin Monitoring
Frequent monitoring of measures of clotting effectiveness (INR) required
* Dose adjustments often are necessary
Narrow therapeutic window, delayed onset (bridging)
Warfarin Reversal Agents
-Vitamin K
-Prothrombin complex concentrate (Kcentra)
-Fresh frozen plasma
Dabigatran [PRADAXA]
DAB is 2 BI
MOA: inhibit thrombin (2a) activity
AE: Bleeding
Reversal: Idarucizumab [PRAXBIND]
Argatroban, Bivalirudin
SAME AS PRADAXA (MOA/AE) but
IV drug and APTT monitoring required
Rivaroxaban, Apixaban, Edoxaban
BAN 10BA
MOA: inhibit factor 10A
AE: Bleeding
Reversal: Andexanet alfa
Unfractionated Heparin
PTAB
MOA: increase degradation of thrombin 2a and factor 10a
AE:
-Bleeding
-Heparin-induced Thrombocytopenia (low platelet count)
Reversal: Protamine sulfate
-APTT monitoring required
Enoxaparin, Dalteparin
U B 10
MOA: same as UFH, more inhibitor of factor 10a
AE: increase bleeding risk
Monitor: anti factor 10a assay
Fondaparinux
I’m fond of 10B10
MOA: inhibits factor 10a only
AE: Bleeding
Monitor: anti factor 10a assay
Alteplase, Tenecteplase
MOA: conversion of plasminogen = plasmin = lysis of thrombi
AE: Bleeding
