Antiviral Agents T-2 Flashcards
Name the drugs used to treat HIV/AIDS:
- reverse transcriptase inhibitors
- protease inhibitors
- nucleosides
- fusion inhibitors
What kind of drug bonds directly to HIV reverse transcriptase blacking bath RNA and DNA dependent DNA polymerase activities?
Reverse transcriptase inhibitors
Contraindications of reverse transcriptase inhibitors:
Pregnancy and lactation
What are some adverse reactions of reverse transcriptase inhibitors?
- headache
- nausea
- vomiting
- rash
- chills
- fever
- diarrhea
What kind of drugs block protease activity within the HIV virus?
Protease inhibitors
What are the contraindications of protease inhibitors?
Pregnancy and lactation
What kind of drug interferes with HIV replication by inhibiting cell protein synthesis?
Nucleosides
What are adverse reactions of nucleosides?
- HA
- insomnia
- dizziness
- nausea
- diarrhea
- fever
- rash
What kind of drug prevents the fusion of the virus with the human cellular membrane?
Fusion inhibitors
What are some adverse reactions to fusion inhibitors?
- HA
- dizziness
- myalgia
- nausea
- vomiting
- diarrhea
What are some drug to drug interactions for fusion inhibitors?
- Pimozide
- rifampin
- triazolam
- midazolam
- oral contrceptive
What is the prototypes for HIV/AIDS antiviral agents?
- Nevirapine
- Fosamprenavir
- Enfuvirtide
- Maraviroc
- Raltegravir
What is the indication for nevirapine?
Treatment if HIV-1 infected patients who have experienced clinical or immunological deterioration, in combination with other antiretrovirals.
What is the indication for fosamprenavir?
Management of adults with symptomatic HIV infection in combination with other antiretrovirals.
What is the indication for enfuvirtide?
Treatment of HIV-1 infected patients who have experienced clinical or immunological deterioration after treatment with other agents, in combination with other antiretrovirals.
