Antiarrhythmic Agnets T-2 Flashcards
Sub - classes of Class I antiarrhythmic drugs are:
- class Ia
- class Ib
- class Ic
Class Ia drugs:
depress phase 0 of the action potential and prolong the action potential duration.
Class Ib drugs:
depress phase 0 somewhat and actually shorten the duration of the action potential
Class Ic drugs:
Markedly depress phase 0, with a resultant extreme slowing of conduction.
What kind of drugs decrease depolarization, decreasing automaticity of the ventricular cells; and increases ventricular fibrillation threshold?
Class I Antiarrhythmic
What are the indications for a class I antiarrhythmic?
management of acute ventricular arrhythmias during cardiac surgery or MI.
Contraindications of Class I antiarrhythmic:
- allergy
- bradycardia
- heart block
- CHF
- hypotension
- shock
- electrolyte disturbances
Cations of Class I antiarrhythmics:
- renal or hepatic dysfunction
- pregnancy
Adverse effects of class I antirrhythmics:
- CNS: dizziness, fatigue, slurred speech
- GI: N/V
- CV: arrhythmias
- Respiratory depression
- Misc: rash, hair loss, potential bone marrow suppression
What kind of drug competitively block beta receptor sites in the heart and kidneys?
- decreases heart rate, cardiac excitability, and cardiac output
- slow conduction though the AV node
Class II Antiarrhythmic
Indications for class II antiarrhythmic?
treatment of SVT and PVC’s.
Contraindications for class II antiarrhythmics:
- sinus Brady
- AVB
- cardiogenic shock
- CHF
- asthma
- respiratory depression
- pregnancy
- lactation
Caution for class II antiarrhythmics:
- diabetes
- thyroid dysfunction
- renal or hepatic dysfunction
Adverse effects for class II antiarrythmics:
- r/t the effects of blocking beta receptors in the sympathetic nervous system
- CNS: dizziness, insomnia dreams, and fatigue
- CV: hypotension, bradycardia, AVB, arrhythmias
- Respiratory: bronchospasm, dyspnea
- GI: N/V, anorexia
- MISC: loss of libido, decreased exercise tolerance, alterations in blood glucose levels
Drug to drug interactions for class II antiarrythmics:
verpamil
What kind of drug blocks potassium channels and slow the outward movement of potassium during phase 3 of the action potential; prolonging action potential.
Class III antiarrhythmics
What are the indications for class III antiarrhythmics:
- life threatening ventricular arrhythmias
- maintenance of sinus rhythm after conversion of atrial arrhythmias
Contraindications for class III antiarrhythmics:
when used for life-threatening arrhythmias there in none.
Cautions for class III antiarrhythmics:
- shock
- hypotension
- respiratory depression
- prolonged QT interval
- renal or hepatic disease
Adverse effects of class III antiarrhythmics:
- N/V
- dizziness
- weakness
- arrhythmia
Drug to drug interactions of class III antiarrhythmics:
- digoxin
- quinidine
What kind of drug blocks the movement of calcium ions across the cell membrane depressing the generation of action potential?
Class IV antiarrhythmic
What are the indications for class IV antiarrhythmics?
- SVT
- control the ventricular response to rapid atrial rates
Contraindications for class IV antiarrhythmics:
- allergy
- sick sinus syndrome
- heart block
- pregnancy
- lactation
- CHF
- hypotension
