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Pharm 161 > Antiarrhythmic Agnets T-2 > Flashcards

Antiarrhythmic Agnets T-2 Flashcards

1
Q

Sub - classes of Class I antiarrhythmic drugs are:

A
  • class Ia
  • class Ib
  • class Ic
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2
Q

Class Ia drugs:

A

depress phase 0 of the action potential and prolong the action potential duration.

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3
Q

Class Ib drugs:

A

depress phase 0 somewhat and actually shorten the duration of the action potential

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4
Q

Class Ic drugs:

A

Markedly depress phase 0, with a resultant extreme slowing of conduction.

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5
Q

What kind of drugs decrease depolarization, decreasing automaticity of the ventricular cells; and increases ventricular fibrillation threshold?

A

Class I Antiarrhythmic

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6
Q

What are the indications for a class I antiarrhythmic?

A

management of acute ventricular arrhythmias during cardiac surgery or MI.

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7
Q

Contraindications of Class I antiarrhythmic:

A
  • allergy
  • bradycardia
  • heart block
  • CHF
  • hypotension
  • shock
  • electrolyte disturbances
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8
Q

Cations of Class I antiarrhythmics:

A
  • renal or hepatic dysfunction

- pregnancy

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9
Q

Adverse effects of class I antirrhythmics:

A
  • CNS: dizziness, fatigue, slurred speech
  • GI: N/V
  • CV: arrhythmias
  • Respiratory depression
  • Misc: rash, hair loss, potential bone marrow suppression
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10
Q

What kind of drug competitively block beta receptor sites in the heart and kidneys?

  • decreases heart rate, cardiac excitability, and cardiac output
  • slow conduction though the AV node
A

Class II Antiarrhythmic

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11
Q

Indications for class II antiarrhythmic?

A

treatment of SVT and PVC’s.

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12
Q

Contraindications for class II antiarrhythmics:

A
  • sinus Brady
  • AVB
  • cardiogenic shock
  • CHF
  • asthma
  • respiratory depression
  • pregnancy
  • lactation
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13
Q

Caution for class II antiarrhythmics:

A
  • diabetes
  • thyroid dysfunction
  • renal or hepatic dysfunction
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14
Q

Adverse effects for class II antiarrythmics:

A
  • r/t the effects of blocking beta receptors in the sympathetic nervous system
  • CNS: dizziness, insomnia dreams, and fatigue
  • CV: hypotension, bradycardia, AVB, arrhythmias
  • Respiratory: bronchospasm, dyspnea
  • GI: N/V, anorexia
  • MISC: loss of libido, decreased exercise tolerance, alterations in blood glucose levels
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15
Q

Drug to drug interactions for class II antiarrythmics:

A

verpamil

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16
Q

What kind of drug blocks potassium channels and slow the outward movement of potassium during phase 3 of the action potential; prolonging action potential.

A

Class III antiarrhythmics

17
Q

What are the indications for class III antiarrhythmics:

A
  • life threatening ventricular arrhythmias

- maintenance of sinus rhythm after conversion of atrial arrhythmias

18
Q

Contraindications for class III antiarrhythmics:

A

when used for life-threatening arrhythmias there in none.

19
Q

Cautions for class III antiarrhythmics:

A
  • shock
  • hypotension
  • respiratory depression
  • prolonged QT interval
  • renal or hepatic disease
20
Q

Adverse effects of class III antiarrhythmics:

A
  • N/V
  • dizziness
  • weakness
  • arrhythmia
21
Q

Drug to drug interactions of class III antiarrhythmics:

A
  • digoxin

- quinidine

22
Q

What kind of drug blocks the movement of calcium ions across the cell membrane depressing the generation of action potential?

A

Class IV antiarrhythmic

23
Q

What are the indications for class IV antiarrhythmics?

A
  • SVT

- control the ventricular response to rapid atrial rates

24
Q

Contraindications for class IV antiarrhythmics:

A
  • allergy
  • sick sinus syndrome
  • heart block
  • pregnancy
  • lactation
  • CHF
  • hypotension
25
Q

Cautions for class IV antiarrhythmics:

A

Idiopathic hypertrophic subaortic stenosis

26
Q

Adverse effects for class IV antiarrhythmics:

A
  • dizziness
  • weakness
  • fatigue
  • depression
  • GI upset
  • hypotension
  • CHF
  • shock
27
Q

Drug to drug interactions for class IV antiarrhythmics:

A

MANY

28
Q

What drug slows calcium from leaving the cell, prolonging the action potential and slowing conduction and heart rate?

A

Digoxin

29
Q

What drug is used to convert SVT to SR when vagal maneuvers have been ineffective?

A

Adenosine (Adenocard)

30
Q

Prototype for class I antiarrhythmic:

A

Lidocaine

31
Q

Prototype for class II antiarrhythmic:

A

propanolol

32
Q

Prototype for class III antiarrhythmic:

A

amiodarone

33
Q

Prototype for class IV antiarrhythmic:

A

diltiazem

Pharm 161 (10 decks)

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