Antianginal Agents T-2

Question 1

What are the actions of antianginal drugs?

Answer 1

• improves blood delivery to the heart muscle by dilating the blood vessels.
• decreases the work load of the heart.

Question 2

Name the types of antianginal drugs:

Answer 2

• Nirates
• Beta-Adrenergic
• Calcium Channel Blockers

Question 3

Factors affecting myocardial oxygen demand are?

Answer 3

• increased heart rate
• increased blood volume
• increased blood pressure
• increased L ventricular muscle size
• increased muscle contractility

Question 4

What antianginals effect increased HR?

Answer 4

• beta-blockers

- calcium channel blockers

Question 5

What antianginals effect increased blood volume?

Answer 5

• beta-blockers
• nitrates
• calcium channel blockers

Question 6

What antianginals effect increased BP?

Answer 6

• beta-blockers
• nitrates
• calcium channel blockers

Question 7

What antianginals effect increased muscle contractility?

Answer 7

• beta-blockers

- calcium channel blockers

Question 8

__________ acts directly on smooth muscle to cause relaxation and depress muscle tone?

Answer 8

nitrates

Question 9

Indications for nitrates:

Answer 9

Prevention and treatment of attacks of angina pectrois

Question 10

Contraindications of nitrates:

Answer 10

• allergy
• severe anemia
• head trauma or cerebral hemorrhage
• pregnancy and lactation

Question 11

Cautions for nitrates:

Answer 11

• hepatic or renal disease

- hypotension, hypovolemia, and conditions that limit cardiac output

Question 12

What are the adverse effects of nitrates:

Answer 12

• related to the vasodilation and decreased in blood flow
• CNS: headache, dizziness, and weakness
• GI: N/V
• CV: hypotension
• Misc: flushing, pallor increased perspiration

Question 13

Drug to drug interactions of nitrates:

Answer 13

• ergot derivatives

- heparin

Question 14

Routes for nitro?

Answer 14

• IV
• sublingual
• translingual spray
• transmucosal spray
• oral, SE tablet
• topical ointment
• transdermal

Question 15

What kind of drug blacks beta-adrenergic receptors in the heart and kidneys; decreases the influence of SNS on these tissues; decreases cardiac output and the release of renin?

Answer 15

Beta blockers!

Question 16

What drug treats stable angina Pretoria and hypertension, prevents reinfarction in MI patients; treats stable CHF?

Answer 16

Beta Blockers!

Question 17

Contraindications of beta blockers:

Answer 17

• bradycardia
• heart block
• cardiogenic shock
• asthma or COPD
• pregnancy and lactation

Question 18

Cautions for beta blockers:

Answer 18

• DM
• PVD
• thyrotoxicosis

Question 19

Adverse effects of beta blockers:

Answer 19

• related to their blockage of sympathetic nervous system
• CNS: dizziness, fatigue, emotional depression
• GI: N/V, decreased cardiac output, and arrhythmias
• CV: CHF, decreased cardiac output, and arrhythmias
• respiratory: bronchospasm, dyspnea, and cough

Question 20

Drug to drug interactions of beta blockers:

Answer 20

• clonidine

Question 21

What kind of drugs inhibit the movement of calcium ions across the membranes of myocardial and arterial muscle cell contraction?

Answer 21

Calcium channel blockers!

Question 22

What are the indications for calcium channel blockers?

Answer 22

Prinzmentals angina

Question 23

Contraindications for calcium channel blocker:

Answer 23

• allergy
• heart block or sick sinus syndrome
• renal or hepatic dysfunction
• pregnancy or lactation

Question 24

Adverse effects of calcium channel blockers:

Answer 24

• hypotension
• cardiac arrhythmias
• GI upset
• skin reactions
• headache

Question 25

Drug to drug interactions of calcium channel blockers:

Answer 25

Vary with each drug!

Question 26

Nitrate prototype:

Answer 26

Nitroglycerin

Question 27

Beta blocker prototype:

Answer 27

Metoprolol

Question 28

Calcium channel prototype:

Answer 28

Diltiazem