Anemia Drugs T-2

Question 1

Insufficient folic acid or vitamin b12 to create the stroll structure needed in a healthy RBC is called?

Answer 1

Megaloblastic anemia

Question 2

A negative iron balance is called?

Answer 2

iron deficiency anemia

Question 3

The gastric mucosa cannot produced intrinsic factor and vitamin B12 cannot be absorbed is called?

Answer 3

pernicious anemia

Question 4

What kind of drug treats anemia associated with renal failure and AIDS, decreases need for blood transfusions in patients undergoing surgery?

Answer 4

erythropoietins

Question 5

What drug acts like the natural glycoprotein erythropoietin to stimulate the production of RBC’s in the bone marrow?

Answer 5

erythropoietins

Question 6

Contraindications for erythropoietins:

Answer 6

• uncontrolled HTN
• allergy to mammalian cell - derived
• allergy to human albumin
• lactation

Question 7

What are the adverse effects of erythropoietins?

Answer 7

• CNS: headache, fatigue, asthenia, dizziness, and seizure
• N/V/D
• CV: HTN, edema, possible chest pain

Question 8

Who is at risk for iron deficiency anemia?

Answer 8

• menstruating women who lose RBC’s monthly
• pregnant and nursing women
• rapidly growing adolescents
• GI bleeding

Question 9

What drug elevates the serum iron concentration?

Answer 9

iron preparations

Question 10

What is the indication for iron preparations?

Answer 10

• treatment of iron deficiency anemias

- adjunct therapy for patient receiving epoetin alfa

Question 11

Contraindications for iron preparations:

Answer 11

• allergy
• hemochromatosis
• hemolytic anemia
• normal iron balance
• peptic ulcer, colitis, or regional enteritis

Question 12

Adverse effects for iron preparations:

Answer 12

• Oral: GI irritation and CNS toxicity
• parental iron is associated with severe anaphylactic reactions, local irritations, staining of the tissues, and phlebitis

Question 13

Drug to drug interactions for iron preparations:

Answer 13

• antacids, tetracyline, cimetidine
• ciprofloxacin, norfloxacin, ofloxacin
• chloramphenicol

Question 14

Causes of folate deficiencies:

Answer 14

• secondary to increased demand
• absorption problems in the small intestine
• drugs that cause folate deficiencies
• secondary to the malnutrition of alcoholism

Question 15

Causes of vitamin b12 deficiencies:

Answer 15

• poor diet and increased demand

- lack of intrinsic factor in the stomach

Question 16

What kind of drugs help cell growth and division for the productions of a strong storm in RBCS?

Answer 16

folic acid derivatives and Vitamin B12

Question 17

What are the indications for folic acid and vitamin B12?

Answer 17

• replacement therapy for dietary deficiencies, pregnancy

- folic acid is used as a rescue drug for cells exposed to some toxic chemotherapeutic agents

Question 18

Adverse effects for folic acid and vitamin B12?

Answer 18

• pain and discomfort at the injection site

- nasal irritation with intranasal spray

Question 19

Prototype for erythropoietins:

Answer 19

Epoetin Alfa

Question 20

Prototype for iron preparations:

Answer 20

ferrous sulfate

Question 21

Prototype for folic acid:

Answer 21

folic acid

Question 22

Prototype for B12:

Answer 22

hydroxocobalamin

Question 23

What drug help with painful crisis and need for blood transfusions in adult patients with sickle cell anemia?

Answer 23

hydroxyurea