Antiphospholipid syndrome Flashcards
1
Q
what is APS
A
autoimmune disorder characterised by arterial and venous thrombosis, adverse pregnancy outcomes and raised levels of antiphospholipid antibodies
2
Q
what does APS often occur secondary to
A
SLE
3
Q
features of APS
A
Clots - usually VTE but also arterial embolism.
Livedo reticularis - mottled appearance on skin
Obstetric loss - recurrent miscarriages
Thrombocytopenia
4
Q
Investigations for APS
A
blood tests looking for anticardiolipin antibodies, anti-beta2-GPI antibodies and positive lupus anticoagulant assay
5
Q
treatment of APS
A
prophylactic aspirin, reduce risks of VTE, lower cardiovascular risk factors
6
Q
what medication to use if patient presents with APS and VTE
A
warfarin, INR 2-3
