Antineoplasics (12) Flashcards
1
Q
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TAMOXIFEN: Nursing Considerations
A
- Peak 4–7 hours
- To decrease GI upset, take after antacid, after evening meal, before bedtime, or take antiemetic 30–60 minutes ahead
- Vaginal bleeding, pruritus, hot flashes are reversible after stopping med
- Contact provider if decreased visual acuity, which may be irreversible
- Tumor flare (increase in tumor size and increased bone pain) may occur, but will decrease rapidly; may take analgesics for pain
- Rx; Preg Cat D
2
Q
TAMOXIFEN: Side Effects
A
- Nausea, vomiting
- Hot flashes, headache
- Rash
- Vaginal discharge
- Vision abnormalities
- Irregular menses
- Fluid retention
- Depression, mood disturbances
- Chest pain
3
Q
TAMOXIFEN: Purpose
A
Management of advanced breast cancer not responsive to other therapy in estrogen-receptor-positive patients
4
Q
METHOTREXATE: Nursing Considerations
A
- PO, IM, IV: onset 4–7 days, peak 7–14 days, duration 21 days
- Avoid crowds and people with known infections
- Do not take with ASA or other NSAIDs, which may cause GI bleeding
- Monitor for pulmonary toxicity, which may manifest early as a dry, nonproductive cough
- Do not take with proton pump inhibitors
- Increase fluid intake to 10–12 glasses/day
- Rx; Preg Cat X
5
Q
METHOTREXATE: Side Effects
A
- Nausea, vomiting, diarrhea
- Anorexia
- Alopecia, rash
- Ulcerative stomatitis
- Dizziness, headache
- Renal abnormalities
- Hepatotoxicity
- Thrombocytopenia
6
Q
METHOTREXATE: Purpose
A
Treatment of cancer, psoriasis, rheumatoid arthritis, and mycosis fungoides
7
Q
CYCLOPHOSPHAMIDE: Nursing Considerations
A
- Use cytotoxic handling procedures
- Avoid evening dosing
- Give antiemetic 30–60 minutes before treatment
- PO: take on an empty stomach
- Monitor temperature every 4 hours
- Increase fluid intake to 2–3 L/day
- Rinse mouth 3–4 times/day for stomatitis
- Avoid aspirin, ibuprofen
- Avoid vaccinations during therapy
- Rx
8
Q
CYCLOPHOSPHAMIDE: Side Effects
A
- Headache, dizziness
- Cardiotoxicity
- SIADH
- Stomatitis
- Nausea, vomiting
- Hepatotoxicity
- Hemorrhagic crisis
- Renal tubular necrosis
- Sterility
- Leukopenia
- Alopecia
- Hyperuricemia
- Pulmonary fibrosis
9
Q
CYCLOPHOSPHAMIDE: Purpose
A
Treatment of cancer
10
Q
CISPLATIN: Nursing Considerations
A
- Use cytotoxic handling procedures
- Give antiemetic 30–60 minutes before treatment
- Monitor temperature every 4 hours
- Increase fluid intake to 2–3 L/day
- Rinse mouth 3–4 times/day for stomatitis
- Avoid vaccinations during therapy
- Rx
11
Q
CISPLATIN: Side Effects
A
- Seizures
- Peripheral neuropathy
- Cardiac abnormalities
- Ototoxicity
- Blurred vision
- Stomatitis
- Nausea, vomiting
- Renal tubular damage
- Thrombocytopenia, leukopenia
- Sterility
- Alopecia
- Hypomagnesemia
- Hypocalcemia
- Hypokalemia
- Hypophosphatemia
- Fibrosis
12
Q
CISPLATIN: Purpose
A
Treatment of advanced bladder cancer, adjunct therapy in metastatic testicular and ovarian cancer
