antimicrobial chemotherapy

Question 1

penicillin examples

Answer 1

benzylpenicilin
amoxicillin
flcloxacillin
co-amoxiclav

Question 2

flucloxacillin uses

Answer 2

staphylococci aureus

Question 3

benzylpenicillin uses

Answer 3

streptococci, neisseria, spriochates

pneumococcal, meningococcal, syphilis

Question 4

ceftriaxone

Answer 4

3rd generation cephalosporin

good gram negative bacilli, hospital infectioons, bacteraemia, pneumonia

Question 5

gentamicin

Answer 5

gram negative bacilli

serious gram - infections e.g. bacteraemia, neutropenic sepsis

Question 6

vancomycin

Answer 6

MRSA

Question 7

co-trimoxazole

Answer 7

PJP

Question 8

linezolid

Answer 8

2nd line MRSA

Question 9

daptomycin

Answer 9

2nd line MSSA

Question 10

rifampicin

Answer 10

meningococcal prophylaxis

complicated staph

Question 11

mentronidazole

Answer 11

giardiasis

trichomonal

Question 12

4 main mechanisms resistance

Answer 12

enzymatic inactivation for drug
modified targets for drugs
reduced permeability to drug
efflux of drug

Question 13

MRSA

Answer 13

penicillin resistant

altered binding protein to normal MSSA

Question 14

mechanism of action: inhibition cell wall synthesis

Answer 14

B-lactams: penicillins and cephlasporins

glycopeptides - vancomycin, teicoplanin

Question 15

mechanism of action: inhibit protein synthesis

Answer 15

aminoglycosides - gentamycin
macrolides - clarithromycin
tetracyclines - doxycycline
oxazolidinones - linezolid

Question 16

mechanism of action: inhibit nucleic acid synthesis

Answer 16

trimethoprim
sulfonamides - sulfamethoxazole
quinolones - ciprofloxacin