Antimicrobial Chemotherapy 3 Flashcards
<p>What has no action against fungi?</p>
<p>Most antibiotics</p>
<p>What are the classes of anti-fungal drugs?</p>
<p>Polyenes</p>
<p>Azoles</p>
<p>Allylamines</p>
<p>Echinocandins</p>
<p>How do polyenes act?</p>
<p>Bind to ergosterol in fungal cell wall and creates a pore</p>
<p>Also binds to other sterols such as cholesterol so are toxic</p>
<p>Why are polyenes toxic?</p>
<p>They bind to sterols such as cholesterol</p>
<p>What are examples of polyenes?</p>
<p>Amphotericin B</p>
<p>Nystatin</p>
<p>How do azoles act?</p>
<p>Inhibit the synthesis of ergosterol</p>
<p>What are examples of azoles?</p>
<p>Fluconazole</p>
<p>Itraconazole</p>
<p>Voriconazole</p>
<p>How do allylamines act?</p>
<p>Supress ergosterol synthesis but act at a different stage of the pathway than azoles (act earlier)</p>
<p>What is an example of an allylamine?</p>
<p>Terbinafine</p>
<p>How do echinocandins act?</p>
<p>Inhibit the synthesis of glucan polysaccharide</p>
<p>What are examples of echinocandins?</p>
<p>Caspofungin</p>
<p>Micafungin</p>
<p>Anidulafungin</p>
<p>How would you describe the number of viral diseases that are treatable?</p>
<p>Few are treatable</p>
<p>What is there none of in terms of treating viruses?</p>
<p>Virucial agents (kill the virus)</p>
<p>What do virucial agents do?</p>
<p>Kill the virus</p>
<p>What do virustatic agents do?</p>
<p>Inhibit the growth</p>
<p>What are many anti-viral drugs?</p>
<p>Nucleoside analogous which interfere with nucleic acid synthesis</p>
<p>What are some anti-viral drugs?</p>
<p>Anti-herpes virus drugs</p>
<p>Anti-HIV drugs</p>
<p>Drugs for chronic hepatitis B and C</p>
<p>Drugs for viral respiratory infections</p>
<p>What are some herpes viruses that there are drugs against?</p>
<p>Herpes simplex virus (HSV)</p>
<p>Cytomegalovirus (CMV)</p>
<p>Varicella-zoster virus (VZV)</p>
<p>Epstein-barr virus (EBV)</p>
<p>How do anti-HIV drugs work?</p>
<p>Nucleoside analogue interfering with the action of reverse transcriptase (slows down replication)</p>
<p>What is a drug used for chronic hepatitis B and C?</p>
<p>Interferon-a is part of the host immune system and is produced by genetic engineering</p>
<p>What are some drugs used for the treatment of influenza A or B?</p>
<p>Zanamivir</p>
<p>Oseltamivir</p>
<p>What is used for the treatment of respiratory syncytial virus (RSV)?</p>
<p>Ribavirin</p>
<p>What is genotype analysis?</p>
<p>Sequencing of part of the viral genome</p>
<p>What can genotypic analysis help with?</p>
<p>Choosing the treatment for patients</p>
