antihelminthic

Question 1

which drug inhibits mitosis in the parasite

Answer 1

Benzimidazole agents

Question 2

which drugs cause paralysis of parasite

Answer 2

Ivermectin, pyrantel pamoate, and praziquantel

Question 3

what nematodes do Albendazole and Mebendazole? how is it treated?

Answer 3

whip worm, hookworm, ascariasis, pinworm: SINGLE HIGH DOSE of either

Question 4

which drug should not be used during preganancy?

Answer 4

Benzimidazole

Question 5

Which drug is the 2nd line drug for strongyloidiasis

Answer 5

Thiabendazole

Question 6

what drug treats cutaneous larval migrans (hookworms) through what route

Answer 6

Thiabendazole topical treatment

Question 7

which is the drug of choice for Strongyloidiasis

Answer 7

Ivermectin

Question 8

What nematodes do Ivermectin target

Answer 8

Filarial worms, B Malayi, O Vovulus, W. Bancrofti, L.Ioa

Question 9

which drug is widely used to tx pinworms

Answer 9

Pyrantel pamoate

Question 10

which drug is the only drug to treat tape worm and flukes? and how is it administered?

Answer 10

Praziquantel

Fluke: 3 doses in a single day
tapeworm: single dose
Cysticercosis: two weeks

Question 11

which drug has serious nephrotoxicity ?

Answer 11

Amphotericin B

Question 12

What chelps Amphotericin B decrease toxcicity

Answer 12

binding to lipid in delivery vehicle

Question 13

through what administration is fungal meningitis treated from amphotericin B

Answer 13

intrathecal

Question 14

which drugs are used to tx local infections of oropharyngela and vaginal candidiasis?

Answer 14

nystatin, clotrimazole, and miconazole

Question 15

which drug treats thrush

Answer 15

Oral Iozenges

Question 16

what nematodes do Fluconazole treat?

Answer 16

Candidiasis, cryptococcosis, coccidiomycosis

Question 17

which drug is 2nd line agent for histoplasmosis, blastomycosis, sporotrichosis

Answer 17

Fluconazole

Question 18

which drug has the the lowest level interaction w/ p450 of all azole–which means widest therapeutic index

Answer 18

Fluconazole

Question 19

which drug is the treatment of choiced that replaced Amotericin B for Aspergillosis?

Answer 19

voriconazole

Question 20

which antifungal drug requires low gastric pH for adsorption

Answer 20

Itraconazole

Question 21

which drug is the drugo choice for Blastomycosis?

Answer 21

ITraconacole

Question 22

which drug has the broadest spectrum of all azoles

Answer 22

Posaconazole

Question 23

what bugs do Posaconazole target

Answer 23

Aspergillus, agent of mucormycoses, Cryptococcus, dimorphic gungi, candida

Question 24

which drug inhibits DNA syntheis

Answer 24

Flucytosine

Question 25

Itraconazole is the drug of choice for which bugs?

Answer 25

Blastomycosis, coccidiomycosis, histoplasmosis, sporotrichosis, dermatophyte

Question 26

what bug does flucytosine mainly target

Answer 26

cryptococcus infectsion, some candida

Question 27

which drug has bone marrow suppression

Answer 27

Flucytosine

Question 28

which drug can treat Cryptococcal Meningities

Answer 28

Flucytosine

Question 29

which drug inhibit beta glucans in order to inhibit fungal cell wall?

Answer 29

Echinocandins

Question 30

what limits Echinocandins effects?

Answer 30

high levels of beta glucans in cell wall

Question 31

which drug is is used to primarily treat invasive infection caused by Candida and aspergillus

Answer 31

Echinocandins

Question 32

which drug is 2nd line tx for dermatophyte infections

Answer 32

Griseofulvin

Question 33

what drugs can treat tinea cruris “jock itch” or tineal corporis “ring worm”

Answer 33

Allylamines

Question 34

which drug is 1st line tx for onychomycosis; and MOA

Answer 34

Terbafine–bound to kertain, provdinging prolonged resistance to fungal invasion

Question 35

where is terbafine mainly concentrated

Answer 35

skin, hairs, nails

Question 36

which antifungals can penetrate CNS

Answer 36

Fluconazole, Flucytosine