antifungal

Question 0

which drug has infused related action adverse effects aka “shake and bake”

Answer 0

ampotericin B

Question 1

which drugs binds to ergosterol and punches holes through the membrane

Answer 1

amphotericin B and nystatin

Question 2

which antifungal has nephrotoxicity

Answer 2

amphotericin B

Question 3

which drugs are most commonly used as topicals for oropharygeal and vaginal candidas

Answer 3

nystatin, miconazole, clotrimazole

Question 4

which drug treats thrush? alternative drug?

Answer 4

nystatin; Lozenges

Question 5

Azoles characteristics

Answer 5

non toxic, inhibition to p450, all broad, resistance: efflux pump, mutation in target enzyme, decrease ergosterol in cell membrane, MOA: inhibit ergosterol synthesis

Question 6

the agents of choice for Fluconazole

Answer 6

candidiasis, cryptococcosis, coccidomycosis

Question 7

which drug has lowest level of interaction of p450 aka widest therapeutic indez

Answer 7

flucanazole

Question 8

2nd line agent for fluconazole

Answer 8

histoplasmosis, blastomycosis, sporotrichosis

Question 9

tx of choice for aspergillosis

Answer 9

voriconazole

Question 10

which drug requires low pH for abdsorption

Answer 10

itraconazole

Question 11

drug of choice for itraconazole

Answer 11

blastomycosis, histoplasmosis, coccidiomycosis, sporptrichosis, onchomycosis

Question 12

which drug has the broadest spectrum of all azoles? what does it typically target

Answer 12

posaconazole; aspergillus, agents of mucormycoses

Question 13

which drug inhibits protein and nucleic acid synthesis (dna synthesis)

Answer 13

Flucytosine

Question 14

which drug treat cryptococcal meningitis

Answer 14

flucytosine

Question 15

which drug has bone marrow suppression adverse effect

Answer 15

flucytosine

Question 16

which drugh inhibits fungal cell wall synthesis

Answer 16

Echinocandins

Question 17

what does echinocandin mainly tx

Answer 17

candida and aspergillus

Question 18

what antifungal drugs can penetrate cns

Answer 18

fluconazole, flucytosine

Question 19

2nd line tx for dermatophyte infection

Answer 19

Griseofulvin

Question 20

which drugs inhibit ergosterol synthesis

Answer 20

azoles and terbinafine

Question 21

which drug is the 1st line drug for onychomycosis

Answer 21

Terbafine

Question 22

what drugs tx tinea cruris, tinea corpis

Answer 22

allylamine:terbafine, naftifine

Question 23

What does nystatin mostly target

Answer 23

Candida

Question 24

What’s the difference between fluconazole and itraconazole

Answer 24

Itraconazole has a broader spectrum than fluconazole but poorer pharmacology and therapeutic index

Question 25

what is itraconazoles effect on rifampin? digoxin? cyclosporine?

Answer 25

decrease rifampin below therapeutic level, raise digoxin and cyclosprine levels

Question 26

what limits Echinocandins effects

Answer 26

high levels of beta glucan in cell wall