Antiemetics Ch.59

Question 1

Describe antiemtics

Answer 1

Reduce hyperactivity of vomiting reflex
 Local effect – decrease response communicating with
medulla
 Mild nausea – antacids, Reglan, etc.
 Central effect – to block chemoreceptor trigger zone
(CTZ)
 Phenothiazines, anticholinergics, antihistamines, serotonin
receptor blockers (5-HT3)

Question 2

What is **prochlorperazine (Compazine)?

Answer 2

Phenothiazines

Question 3

What are therapeutic actions of prochlorperazine (Compazine)?

Answer 3

Central acting  block CTZ

Question 4

What are adverse effects of prochlorperazine (Compazine)?

Answer 4

Monitor CNS effects  drowsiness, dizziness
 CAREFUL use with other CNS medications

Question 5

What are contras of prochlorperazine (Compazine)?

Answer 5

CNS depression

Question 6

What are cautions of prochlorperazine (Compazine)?

Answer 6

Hypo or hypertension

Question 7

What is odansetron (Zofran)?

Answer 7

5-HT3 (SEROTONIN) RECEPTOR
BLOCKERS

Question 8

What is therapeutic actions of odansetron (Zofran)?

Answer 8

Block receptors associated with nausea and vomiting in CTZ and locally

5-HT3 (SEROTONIN) RECEPTOR
BLOCKERS

Question 9

What is indications of odansetron (Zofran)?

Answer 9

Chemo & radiation related N/V
 Post-op N/V

5-HT3 (SEROTONIN) RECEPTOR
BLOCKERS

Question 10

What is adverse effects of odansetron (Zofran)?

Answer 10

Monitor for HA, pain at injection site, hypotension, constipation

5-HT3 (SEROTONIN) RECEPTOR
BLOCKERS

Question 11

What is contras of odansetron (Zofran)?

Answer 11

Allergy

5-HT3 (SEROTONIN) RECEPTOR
BLOCKERS

Question 12

What is cautions of odansetron (Zofran)?

Answer 12

pregnancy

5-HT3 (SEROTONIN) RECEPTOR
BLOCKERS