Antibiotics

Question 1

Quinolones

Answer 1

inactivate DNA gyrase preventing super coiling which also prevents DNA replication

Question 2

Rifampin

Answer 2

Binds to RNA polymerase preventing mRNA synthesis

Question 3

Sulfamide (Sulfa drugs)

Answer 3

Bind in place of PABA acting as a competitive inhibitor, disrupting folic acid synthesis

Question 4

Polymyxin B

Answer 4

Poor selective toxicity, used in ointments

Binds to phospholipids compromising membrane integrity and function

Question 5

Beta Lactams

Answer 5

Interfere with an enzyme required for PG synthesis resulting in cell lysis

Question 6

Non-beta Lactams

Answer 6

Interfere at various steps in PG synthesis

Includes Cycloserine, Bacitracin, Vancomycin

Question 7

Sulfonamide + Trimethoprim

Answer 7

Antibiotic cocktail with a broader spectrum and reduced toxicity because it works on two points of the same pathway (reduces chances of resistance)