Anti-Thrombotic Drugs Flashcards
1
Q
Common ADP receptor (P2Y12) antagonist
A
Clopidogrel
2
Q
G-IIb-IIIa Inhibitors
A
Abciximab
3
Q
Fondaparinux targets what portion of the coagulation cascade? Why?
A
Xa; shortest heparin, so can only bind Xa
4
Q
LMWH and Heparin targets what portion of the coagulation cascade
A
Xa and Thrombin
5
Q
Warfarin targets what portion of the coagulation cascade
A
II (thrombin), VII, IX, X
6
Q
Examples of Direct Thrombin Inhibitiors
A
Argatroban
Dabigatran
7
Q
Examples of Factor Xa inhibitors
A
Rivaroxaban
Apixiban
8
Q
Fondaparinux has (long/short) duration of action
A
Long
9
Q
Why must Warfarin be bridged with heparin?
A
Also inhibits Protein C and S synthesis (anti-thrombics), so temporarily caused a pro-thrombic state in patients