Anti TB and Anti Hansens

Question 1

Mechanism of resistance to isoniazod

Answer 1

Overexpression of inhA
Mutation or deletion of KatG
Mutation of kasA

Question 2

Mechanism of action of rifampicin

Answer 2

Inhibits initiation of RNA synthesis

Question 3

Rifampicin is mainly excreted in

Answer 3

Bile and feces

Question 4

The active form of pyrazinamide

Answer 4

Pyrazinoic acid

Question 5

What converts isoniazid to active form

Answer 5

KatG

Question 6

Which three anti TB drugs cause hepatotoxicity

Answer 6

Isoniazid
Rifampicin
Pyrazinamide

Question 7

Major side effects of PZN

Answer 7

Hepatotoxicity
Ototoxicity
Hyperuricemia

Question 8

The only antiTB drug administered parenterally

Answer 8

Streptomycin

Question 9

Major adverse effect of streptomycin

Answer 9

Ototoxicity

Question 10

Mode of action of ethambutol

Answer 10

Tuberculostatic

Question 11

AntiTB drugs contraindicated in pregnancy

Answer 11

Streptomycin and pyrazinamide

Question 12

TB treatment in HIV when rifampicin is contraindicated

Answer 12

Rifabutine

Question 13

Chief secondary drug for sulfone resistant hansenites

Answer 13

Clofazimine

Question 14

WHO standard for chemotherapy of leprosy for paucibacillary form

Answer 14

Dapsone and rifampicin

Question 15

WHO chemotherapy for multibacillary form of leprosy

Answer 15

Rifampicin dapsone and clofazimine

Question 16

Most frequent major side effect of isoniazid

Answer 16

Hepatitoxicity

Question 17

MOA of isoniazid

Answer 17

Inhibits DNA synthesis by inhibitung mycolase synthetase

Question 18

Isoniazid is activates by

Answer 18

KatG

Question 19

Isoniazid is acetylates in the lover by

Answer 19

Acetyl hydrazine

Question 20

ADRs of isoniazid

Answer 20

Peripheral neuritis
Hepatotoxicity
Pyridoxine deficiency

Question 21

Rifampicin is mainly excreted in

Answer 21

Bile and feces

Question 22

Side effect of rifampicin

Answer 22

Hepatotoxicity

Urine and tears discoloration

Question 23

Difference of isoniazid and rifampicin when considering microsomal enzyme

Answer 23

Isoniazid is a hepatic microsomal enzyme inhibitor

Rifampicin is a hepatic microsomal enzyme inducer

Question 24

Adverse effect or pyrazinamide

Answer 24

Hepatic injury

Hyperuricemia

Question 25

Clinical use of pyrazinamide

Answer 25

Residual intracellular organisms that may cause relapse

Question 26

ADRs of streptomycin

Answer 26

Nephro Oto Facial paresthesias

Question 27

MOA of ethambutol

Answer 27

Inhibitis mycobacterial arabinosul transferase | Tuberculostatic

Question 28

ADRs of ethambutol

Answer 28

Optic neuritis | Hyperuricemia

Question 29

Contraindicated drugs during pregnanxy

Answer 29

Pyrazynamide | Streptomycin

Question 30

For TB treatment in HIV when rifampicin is contraindicated

Answer 30

Rifabutine

Question 31

MOA of dapsone

Answer 31

Inhibit folic acid synthesis

Question 32

Chief secondary drug for sulfone resistant patient

Answer 32

Clofazimine

Question 33

Type of hypersensitivity present in tupe II leprosy reaction

Answer 33

Hypersensitivity type III or immune complex mediated

Question 34

What drug prevents erythema nudosum

Answer 34

Clofazimine