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2nd Year - Pharmacology > Anti TB and Anti Hansens > Flashcards

Anti TB and Anti Hansens Flashcards

1
Q

Mechanism of resistance to isoniazod

A

Overexpression of inhA
Mutation or deletion of KatG
Mutation of kasA

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2
Q

Mechanism of action of rifampicin

A

Inhibits initiation of RNA synthesis

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3
Q

Rifampicin is mainly excreted in

A

Bile and feces

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4
Q

The active form of pyrazinamide

A

Pyrazinoic acid

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5
Q

What converts isoniazid to active form

A

KatG

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6
Q

Which three anti TB drugs cause hepatotoxicity

A

Isoniazid
Rifampicin
Pyrazinamide

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7
Q

Major side effects of PZN

A

Hepatotoxicity
Ototoxicity
Hyperuricemia

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8
Q

The only antiTB drug administered parenterally

A

Streptomycin

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9
Q

Major adverse effect of streptomycin

A

Ototoxicity

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10
Q

Mode of action of ethambutol

A

Tuberculostatic

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11
Q

AntiTB drugs contraindicated in pregnancy

A

Streptomycin and pyrazinamide

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12
Q

TB treatment in HIV when rifampicin is contraindicated

A

Rifabutine

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13
Q

Chief secondary drug for sulfone resistant hansenites

A

Clofazimine

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14
Q

WHO standard for chemotherapy of leprosy for paucibacillary form

A

Dapsone and rifampicin

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15
Q

WHO chemotherapy for multibacillary form of leprosy

A

Rifampicin dapsone and clofazimine

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16
Q

Most frequent major side effect of isoniazid

A

Hepatitoxicity

17
Q

MOA of isoniazid

A

Inhibits DNA synthesis by inhibitung mycolase synthetase

18
Q

Isoniazid is activates by

A

KatG

19
Q

Isoniazid is acetylates in the lover by

A

Acetyl hydrazine

20
Q

ADRs of isoniazid

A

Peripheral neuritis
Hepatotoxicity
Pyridoxine deficiency

21
Q

Rifampicin is mainly excreted in

A

Bile and feces

22
Q

Side effect of rifampicin

A

Hepatotoxicity

Urine and tears discoloration

23
Q

Difference of isoniazid and rifampicin when considering microsomal enzyme

A

Isoniazid is a hepatic microsomal enzyme inhibitor

Rifampicin is a hepatic microsomal enzyme inducer

24
Q

Adverse effect or pyrazinamide

A

Hepatic injury

Hyperuricemia

25
Q

Clinical use of pyrazinamide

A

Residual intracellular organisms that may cause relapse

26
Q

ADRs of streptomycin

A

Nephro
Oto
Facial paresthesias

27
Q

MOA of ethambutol

A

Inhibitis mycobacterial arabinosul transferase

Tuberculostatic

28
Q

ADRs of ethambutol

A

Optic neuritis

Hyperuricemia

29
Q

Contraindicated drugs during pregnanxy

A

Pyrazynamide

Streptomycin

30
Q

For TB treatment in HIV when rifampicin is contraindicated

A

Rifabutine

31
Q

MOA of dapsone

A

Inhibit folic acid synthesis

32
Q

Chief secondary drug for sulfone resistant patient

A

Clofazimine

33
Q

Type of hypersensitivity present in tupe II leprosy reaction

A

Hypersensitivity type III or immune complex mediated

34
Q

What drug prevents erythema nudosum

A

Clofazimine

2nd Year - Pharmacology (18 decks)

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