Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

2nd Year - Pharmacology > Adrenergic neuron blockers and ganglionic blockers > Flashcards

Adrenergic neuron blockers and ganglionic blockers Flashcards

1
Q

Adrenergic neuron blockade MOA: Guanethedine

A

Inhibit NE release from adrenergic nerve terminals
Deplete catecholamine stores
Forms false neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Adrenergic neuron blockade MOA: Bretylium

A

Inhibit NE release from adrenergic nerve terminals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Adrenergic neuron blockade MOA: Reserpine

A

Deplete catecholamine stores

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Adrenergic neuron blockade MOA: Methyldopa

A

Deplete catecholamine stores

Forms false neurotransmitters

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Adrenergic neuron blockade MOA: Pargyline

A

MAO inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Adrenergic neuron blockade MOA: Metyltyrosine

A

Interfere with catecholamine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Adrenergic neuron blockade MOA: 6-Hydroxydopamine

A

Destroy adrenergic nerve fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adrenergic neuron blocker which is worst for orthostatic hypotension ADR

A

Guanethedine and congeners

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Reserpine: solubility, MOA, ADR, effect on CVS/Brain/GIT

A

Readily enters the brain
MOA: Irreversibly binds tightly to adrenergic storage vesicles: depletion of catecholamines in CNS and adrenal medulla
ADR: Extrapyramidal symptoms, Depression
CVS: decreased HR, CO, PVR, BP
-Salt and water retention–> pseudotolerance, edema
Brain: sedation, EPS, depression
GIT: parasympathetic predominance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Methyldopa: indication, MOA, ADR

A

Indication: Hypertension during pregnancy
MOA: central a2 agonist: decrease PVR; false neurotransmitter
ADR: Sedation at onset, EPS, amenorrhea, postural hypotension, lactation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Guanethedine: Indication, solubility, MOA

A

Indication: severe form of hypertension
Polar, cannot cross BBB, no sedation
Bretylium-like: blocks NE release by blocking impulse conduction in nerve terminals
Cocaine-like: inhibits neuronal uptake
Reserpine-like: catecholamine depletion
Tyramine-like: rapid release of NE from stores (sympathomimetic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Guanethedine: ADR

A

Profound sympathoplegia

Pharmacologic sympathectomy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Metyrosine: MOA

A

Inhibits tyrosine hydroxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

6-Hydroxydopamine: MOA

A

selectively neurotoxic for noradrenergic terminals
Converted to quinone–> chemical sympathectomy
Destruction of nerve fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Treatment of lifethreatening ventricular arrhytmias that dont respond to lidocaine or procainamide

A

Bretylium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

currently licensed as an orphan drug for Tourette’s syndrome

A

Mecamylamine

17
Q

MOA of Trimetaphan

A

Competitive ganglionic blocker

2nd Year - Pharmacology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions