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2nd Year - Pharmacology > 3.01 - Cancer Therapeutics > Flashcards

3.01 - Cancer Therapeutics Flashcards

1
Q

Classification of anticancer drugs that are schedule dependent

A

Cell cycle specific drugs

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2
Q

Enumerate cell cycle specific drugs

A

Antimetabolites
Bleomycin
Plant alkaloids
Hormones

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3
Q

Enumerate cell cycle non specific drugs

A

Alkylating agents

Antitumor antibiotics except bleomycin

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4
Q

Rationale behind debulking procedures

A

Recruits cells to divide to make them responsive to anticancer drugs by reducing number/mass of cells

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5
Q

Diagnosis is usually done at what exponential log phase

A

10 to the 9th

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6
Q

Two cancers that can be treated by a single drug

A

Choriocarcinoma

Burkitt’s lymphoma

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7
Q

Treatment for choriocarcinoma

A

Methotrexate

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8
Q

Treatment of burkitt’s lymphoma

A

Cyclophosphamide

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9
Q

Treatment regimen for lung cancer

A

ECV

  • Etoposide
  • Cisplatin
  • Vincristine
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10
Q

Treatment regimen for breast cancer

A

CMF

  • Cyclophosphamide
  • Methotrexate
  • Fluorouracil
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11
Q

Anticancer drugs that don’t usually cause myelosuppression

A 
Vincristine
Bleomycin
Streptozocin
Hormones
Asparaginase
Cisplatin
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12
Q

Treatment for nausea and vomiting caused by anticancer drugs

A

Ondansetron

Granisetron

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13
Q

Enumerate classification of anticancer drugs

A 
Antimetabolites
Alkylatinf agents
Antitumor antibiotics
Natural products
Hormones
Targeted therapies
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14
Q

Single most effective agent for induction of remission in AML

A

Cytarabine

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15
Q

Broadest spectrum of activity of all alkylating agents

A

Cyclophosphamide

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16
Q

Metabolite of cyclophosphamide that causes sterile hemorrhagic cystitis

A

Acrolein

17
Q

Antidote to acrolein accumulation in the bladder

A

MESNa+

18
Q

Most important MOA of antitumor antibiotics

A

Intercalation

19
Q

Cardiotoxic side effect of antitumor antibiotics is seen in

A

Anthracyclines

20
Q

Antidote to cardiotoxic ADR of anthracycline

A

Dexrazoxane

21
Q

PDGF Targeted inhibitors

A

TKI: imatinib

22
Q

HER-2 inhibitor

A

Receptor inhibitor: trastuzumab

Tyrosine kinase inhibitor: lapatinib

23
Q

EGF inhibitors

A

Receptor inhibitor: cetuximab

Tyrosine kinase inhibitor: erlotinib, gefitinib

24
Q

VEGF inhibitor

A

Receptor inhibitor: becacizumab

Tyrosine kinase inhibitor: sunitinib, sorafenib, pazopanin

25
Q

Classification of anticancer drugs that are dose- dependent

A

Cell cycle non-specific drugs

2nd Year - Pharmacology (18 decks)

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