2. Antimalarial Drugs Flashcards
Mefloquine is contraindicated in __
Epilepsy or seizure disorder
Severe psychiatric disorder
This antimalarial deug is administed for the hypozoite stage of plasmodium vivax and ovale to prevent relapse. Used in relapsing malria for radical cure
Primaquine phosphate
Quinghaosu is very good for
Cerebral falciparum malaria and chloroquine resistant strains
Antimalarial drugs that can be given to pregnant women in all trimesters
Quinine chloroquine Artesunate Artemether Arterther
Antimalarial drug given to pregant mothers in 2nd or 3rd trimesters
Mefloquine
Pyrimethamone
Sulfadoxine
Antimalarial drugs contraindicated for pregnant women
Primaquine
Tetracycline
Doxycycline
Halofantrine
Only antimalarial drug used in congenital and neonatal malaria
Chloroquine
Excretion of mefloquine is through
Feces and bile
Antimalarial causal prophylactic drugs
Chlorguanide
Pyrimethamine
Blood schizonticides
Quinine
Chloroquine
Mefloquine
Halofantrine
Radical cure
Chloroquine
Quinine
Primaquine
Treatment for persistent hypnozoites
Primaquine
Antimalarial clinical prophylactic drugs
Quinine
Chloroquine
P. Falciparum is resistant to
Chloroquine
ADR of quinine
Cinchonism
Blackwater fever
Cardiivascular collapse
Interaction of quinine with warfarin
Increased warfarin action due to decreased vitamin synthesis
Parenteral dose limit for chloroquine
5 grams
Excretion of mefloquine
Feces and bile
ADRs of mefloquine
Neurological and psychiatric effects
Interactions of mefloquine
Chloroquine: convulsions and CVS effects
Halofantrine: fatal long QT
Valproic acid: decreased effect if VA causing seizures
Mefloquine is contraindicated in
Seizure disorder
Psychiatric disorder
Irregular heart beats
Children below 2 years old
Used for highly resistant malarias
Mefloquine
HALOFANTRINE
Used for relapsing malaria (ovale and vivax)
Primaquine phosphate
Blood schuzonticide very effective against cerebral malaria falciparum, vs all types, including chloroquine resistant strains; not used in pregnancy
Quinghaosu (artemesin)
Only antimalarial agent for congenital and neonatal malaria
Chloroquine
May cause kernicterus in infanta less than 2 months
Fansidar (sulfa + pyrimethamine)
Malaria affecting all RBC
Falciparum
Malaria affecting young RBC
Vivax
Malaria affecting mature RBC
Malariae
Malaria effecting old RBC
Ovale
Plasmodium species characterized by crescent shaped gametocyte
Falciparum
Plasmodium stage infective to humans
Sporozoites
Radical cure for vivax and ovale
Primaquine
