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2nd Year - Pharmacology > 2. Antimalarial Drugs > Flashcards

2. Antimalarial Drugs Flashcards

1
Q

Mefloquine is contraindicated in __

A

Epilepsy or seizure disorder

Severe psychiatric disorder

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2
Q

This antimalarial deug is administed for the hypozoite stage of plasmodium vivax and ovale to prevent relapse. Used in relapsing malria for radical cure

A

Primaquine phosphate

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3
Q

Quinghaosu is very good for

A

Cerebral falciparum malaria and chloroquine resistant strains

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4
Q

Antimalarial drugs that can be given to pregnant women in all trimesters

A 
Quinine 
chloroquine 
Artesunate
Artemether
Arterther
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5
Q

Antimalarial drug given to pregant mothers in 2nd or 3rd trimesters

A

Mefloquine
Pyrimethamone
Sulfadoxine

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6
Q

Antimalarial drugs contraindicated for pregnant women

A

Primaquine
Tetracycline
Doxycycline
Halofantrine

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7
Q

Only antimalarial drug used in congenital and neonatal malaria

A

Chloroquine

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8
Q

Excretion of mefloquine is through

A

Feces and bile

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9
Q

Antimalarial causal prophylactic drugs

A

Chlorguanide

Pyrimethamine

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10
Q

Blood schizonticides

A

Quinine
Chloroquine
Mefloquine
Halofantrine

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11
Q

Radical cure

A

Chloroquine
Quinine
Primaquine

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12
Q

Treatment for persistent hypnozoites

A

Primaquine

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13
Q

Antimalarial clinical prophylactic drugs

A

Quinine

Chloroquine

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14
Q

P. Falciparum is resistant to

A

Chloroquine

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15
Q

ADR of quinine

A

Cinchonism
Blackwater fever
Cardiivascular collapse

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16
Q

Interaction of quinine with warfarin

A

Increased warfarin action due to decreased vitamin synthesis

17
Q

Parenteral dose limit for chloroquine

A

5 grams

18
Q

Excretion of mefloquine

A

Feces and bile

19
Q

ADRs of mefloquine

A

Neurological and psychiatric effects

20
Q

Interactions of mefloquine

A

Chloroquine: convulsions and CVS effects
Halofantrine: fatal long QT
Valproic acid: decreased effect if VA causing seizures

21
Q

Mefloquine is contraindicated in

A

Seizure disorder
Psychiatric disorder
Irregular heart beats
Children below 2 years old

22
Q

Used for highly resistant malarias

A

Mefloquine

HALOFANTRINE

23
Q

Used for relapsing malaria (ovale and vivax)

A

Primaquine phosphate

24
Q

Blood schuzonticide very effective against cerebral malaria falciparum, vs all types, including chloroquine resistant strains; not used in pregnancy

A

Quinghaosu (artemesin)

25
Q

Only antimalarial agent for congenital and neonatal malaria

A

Chloroquine

26
Q

May cause kernicterus in infanta less than 2 months

A

Fansidar (sulfa + pyrimethamine)

27
Q

Malaria affecting all RBC

A

Falciparum

28
Q

Malaria affecting young RBC

A

Vivax

29
Q

Malaria affecting mature RBC

A

Malariae

30
Q

Malaria effecting old RBC

A

Ovale

31
Q

Plasmodium species characterized by crescent shaped gametocyte

A

Falciparum

32
Q

Plasmodium stage infective to humans

A

Sporozoites

33
Q

Radical cure for vivax and ovale

A

Primaquine

2nd Year - Pharmacology (18 decks)

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