2.02 - Antimicrobials Flashcards
Drug of choice for shigella
Ampicillin q6hours stays longer in the GIT
Clearance of nafcillin is via __
Biliary clearance
Specific ADR of nafcillin
Neutropenia
Specific ADR of oxacillin
Hepatitis
Specific ADR of methicillin
Interetitial nephritis
Cephalosporin effective against pseudomonas
Ceftazidime
Penicillin binding protein responsible for maintaining the bacterial wall’s constant diameter
PB1
Pencillin binding protein responsible for extending the bacterial cell wall in any direction
PBP2
Beta lactam that binds to PBPs
Carbapenems
Drug of choice for enterobacter
Carbapenems
side effect of __ is gray baby syndrome
Chloramphenicol
Major side effect of lincosamides
Pseudomembranous colitis
Identify antimicrobial group effective against amoeba, amoeba-like organisms and anaerobes; also notorious for disulfiram-like reactions
Metronidazole
Drug of choice for campylobacter, mycoplasma, or legionella, and atypical pneumonia
Macrolides
__ is adjunct in treatment of gastroparesis
Macrolides (erythromycin)
Macrolide that is highly active against chlamydia sp.
Azithromycin
Given for scalded skin syndrome and other staph infections
Penicillinase resistant penicillins
- nafcillin
- oxacillin
- cloxacillin
- flucloxacillin
Mode and mechanism of action of quinolones
Bactericidal
Imhibitid DNA gyrase (topoisonerase II and IV).
Mode of action of sulfonamides
Inhibits folic acid synthesis by competitive inhibitor of dihydropteroate synthetase
Mode of action of diaminopyrimidines
Inhibit folic acid synthesis by selective inhibituib of bacterial dihydrofolate reductase
Drug of choice for mycoplasma, chlamydia, rickettsia, and vibrios
Tetracyclines
Enamel dysplasia is a side effect of __
Tetracycline
Spectrum of antimicrobial activity if vancomycin
Narrow - effective only against cocci
Drug of choice for residtant gram positive cocci (MRSA, penicillin resistant pneumococci, and clostridiun difficile
Vancomycin
