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2nd Year - Pharmacology > 2.02 - Antimicrobials > Flashcards

2.02 - Antimicrobials Flashcards

1
Q

Drug of choice for shigella

A

Ampicillin q6hours stays longer in the GIT

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2
Q

Clearance of nafcillin is via __

A

Biliary clearance

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3
Q

Specific ADR of nafcillin

A

Neutropenia

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4
Q

Specific ADR of oxacillin

A

Hepatitis

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5
Q

Specific ADR of methicillin

A

Interetitial nephritis

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6
Q

Cephalosporin effective against pseudomonas

A

Ceftazidime

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7
Q

Penicillin binding protein responsible for maintaining the bacterial wall’s constant diameter

A

PB1

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8
Q

Pencillin binding protein responsible for extending the bacterial cell wall in any direction

A

PBP2

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9
Q

Beta lactam that binds to PBPs

A

Carbapenems

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10
Q

Drug of choice for enterobacter

A

Carbapenems

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11
Q

side effect of __ is gray baby syndrome

A

Chloramphenicol

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12
Q

Major side effect of lincosamides

A

Pseudomembranous colitis

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13
Q

Identify antimicrobial group effective against amoeba, amoeba-like organisms and anaerobes; also notorious for disulfiram-like reactions

A

Metronidazole

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14
Q

Drug of choice for campylobacter, mycoplasma, or legionella, and atypical pneumonia

A

Macrolides

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15
Q

__ is adjunct in treatment of gastroparesis

A

Macrolides (erythromycin)

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16
Q

Macrolide that is highly active against chlamydia sp.

A

Azithromycin

17
Q

Given for scalded skin syndrome and other staph infections

A

Penicillinase resistant penicillins

  • nafcillin
  • oxacillin
  • cloxacillin
  • flucloxacillin
18
Q

Mode and mechanism of action of quinolones

A

Bactericidal

Imhibitid DNA gyrase (topoisonerase II and IV).

19
Q

Mode of action of sulfonamides

A

Inhibits folic acid synthesis by competitive inhibitor of dihydropteroate synthetase

20
Q

Mode of action of diaminopyrimidines

A

Inhibit folic acid synthesis by selective inhibituib of bacterial dihydrofolate reductase

21
Q

Drug of choice for mycoplasma, chlamydia, rickettsia, and vibrios

A

Tetracyclines

22
Q

Enamel dysplasia is a side effect of __

A

Tetracycline

23
Q

Spectrum of antimicrobial activity if vancomycin

A

Narrow - effective only against cocci

24
Q

Drug of choice for residtant gram positive cocci (MRSA, penicillin resistant pneumococci, and clostridiun difficile

A

Vancomycin

25
Q

DOC for salmonella

A

Aminopenicillins

26
Q

DOC for salmonella

A

Aminopenicillins

27
Q

Drugs for pseudomonas

A

Aminoglycosides
3rd gen cephaloaporin
Extended spectrum penicillins

28
Q

Most important drug interaction with tetracycline

A

Antacids (magnesium and aluminum)
Milk (calcium)
Very young (teeth and bones with calcium)

29
Q

Which antimalarial drug cannot be given to pregnant mothers in 3rd trimester

A

Quinine

2nd Year - Pharmacology (18 decks)

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