1.04 - Pharmacokinetics 1 and 2

Question 1

Enumerate the four pharmacokinetic parameters

Answer 1

Absorption
Distribution
Metabolism
Elimination

Question 2

Pharmacokinetic parameter that involves the passage of the drug from its site of administration into the circulation

Answer 2

Absorption

Question 3

__ is the major factor that will influence absorption

Answer 3

Route of administration

Question 4

___ is the carrier protein to which weak acids like warfarin, mefenamic acid, aspirin, vitamin c, and NSAIDs bind to during facilitated diffusion

Answer 4

Albumin

Question 5

___ is the carrier protein to which weak bases like antacids, valium, naproxen, and diazepam bind to during facilitated diffusion

Answer 5

alpha globulin

Question 6

If pH is (greater than or less than) pKa for weak acids, the weak acids can be absorbed in the membrane

Answer 6

Less than

Question 7

If pH is (greater than or less than) pKa for weak bases, the weak bases can be absorbed in the membrane

Answer 7

Greater than

Question 8

Urinary (acidification or alkalinization) accelerates excretion of weak bases

Answer 8

Acidification

Question 9

Urinary (acidification or alkalinization) accelerates excretion of weak acids

Answer 9

Alkalinization

Question 10

What is the bioavailability % of intravenously administered drugs?

Answer 10

100%

Question 11

What is the bioavailability % of intramuscularly administered drugs?

Answer 11

75 to less than or equal to 100%

Question 12

What is the bioavailability % of subcutaneously administered drugs?

Answer 12

75 to less than or equal to 100 %

Question 13

What is the bioavailability % of orally administered drugs?

Answer 13

5 to less than 100%

Question 14

What is the bioavailability % of rectally administered drugs?

Answer 14

30 to less than 100%

Question 15

What is the bioavailability % of transdermally administered drugs?

Answer 15

80 to less than or equal to 100%

Question 16

Generally speaking, in the presence of food, absorption is ____ (decreased or increased)

Answer 16

Decreased since food delays gastric emptying time

Question 17

If taken with food, amoxicillin and paracetamol absorption is ___ (delayed, reduced, enhanced)

Answer 17

Delayed absorption of amoxicillin and paracetamol with food

Question 18

If taken with food, ampicillin, digoxin, and doxycycline absorption is ___ (delayed, reduced, enhanced)

Answer 18

Reduced absorption

Question 19

If taken with food, aspirin, beta-blockers and diazepam absorption is ___ (delayed, reduced, enhanced)

Answer 19

Enhanced absorption

Question 20

Calcium and Magnesium-containing antacids chelate ___ rendering __ inactive

Answer 20

Tetracyclines

Question 21

___ are degraded form of the drug

Answer 21

Metabolites

Question 22

___ is the natural substrate for weak bases or organic cations for excretion in the proximal tubule of the kidneys

Answer 22

Histamine

Question 23

___ is the natural substrate for weak acids or organic anions for excretion in the proximal tubule of the kidneys

Answer 23

Uric acid