Anti-inflammatory Medication Flashcards
what are NSAID general mechanism?
block cyclooxygenase at both central and peripheral sites
what do NSAID specifically blocks?
prostaglandins and thromboxane
blockade of prostaglandin formation results in ?
moderate anti-inflammatory, analgesic and anti-pyretic effects
blockade of thromboxane causes?
inhibition of platelet activation - Decreases likelihood of formation of clots
what is a “housekeeping” enzyme that is always present and regulated in a variety of tissues?
COX-1
what is an “induced” enzyme that is mostly produced by immune cells in response to inflammation?
COX-2
most COX-inhibitors block both ?
COX-1 and COX-2
what are associated with development of heart attacks and strokes more often than most non-selective medications
selectively COX-2 inhibitors
what is the only selective COX-2 inhibitor approved in Canada?
celcoxib (Celebrex)
Why do NSAIDS (COX-2 inhibitors and many other common NSAIDS) increase the risk of heart attack?
inhibition of PGI2 formation
The GI toxicity of oral systemic NSAIDs can be severe in those with a history of ?
bleeding peptic ulcers
how can you take NSAIDS if you have a history of bleeding peptic ulcers
- Patients can take the NSAID with an antacid that reduces the risk of GI damage
- Patients can take the NSAID with a medication that activates prostaglandin receptors in the GI tract
what is the mechanism of action of clucocorticoids?
block of PLA2
what is the therapeutic use of clucocorticoids?
Relief of inflammation or flares in autoimmune disease
Glucocorticoids are analogues of ?, which is released by your ?
cortisol
adrenal cortex
