AnP Chapter 10 (LO8) Flashcards
Body contains over ——muscles which comprise about –% of adults weight
Body contains over 600 muscles which comprise about 40% of adults weight
3 TYPES OF MUSCLES
Cardiac muscle
Smooth muscle
Skeletal muscle
Cardiac muscle
Found only in heart
Consists of short, branching fibers that fit together at intercalated discs
Striated
Is a type of involuntary muscle because it contracts automatically
Smooth muscle
Found in digestive tract, blood vessels, bladder, airways and uterus
Nonstriated
Involuntary muscle
Skeletal muscle
Attached to bone and causes movement of the body
Voluntary: contracted at will
SKELETAL MUSCLE STRUCTURE
Consists of bundles of tiny fibers that run the length of muscle
Most fibers are about 3cm long and 0.05mm wide
Endomysium
delicate connective tissue that covers each muscle
Fascicles
muscle fibers grouped in bundles
Perimysium
a sheath of tougher connective tissue that encases fascicles
Epimysium
layer of connective tissue that surrounds and binds all the muscle fiber together
Fascia
connective tissue that surrounds the muscle outside the epimysium
Deep fascia
lies between muscles
Superficial fascia
resides just underneath the skin
Skeletal may attach to bone in 1 of 2 ways
Direct attachment
Indirect attachment
Direct attachment
Indirect attachment
Direct attachment: muscle fibers merge with the periosteum of the bone forming a strong attachment
Indirect attachment: the epimysium extends past the muscle as a tendon
STRUCTURE OF MUSCLE FIBERS
Muscle cells are called muscle fibers because they’re long, thread like
Have multiple nuclei pressed against the side of the plasma membrane
Complex interior
Sarcolemma
the plasma membrane surrounding each fiber
Sarcoplasm
cytoplasm of the cell
Myofibrils
long protein bundles that fill the sarcoplasm
Store glycogen (used for energy) and 02
Sarcoplasmic reticulum (SR)
smooth endoplasmic reticulum of a muscle fiber
Surrounds each myofibril
Where calcium ions are stored
Myofilaments:
2 types thick and thin
Myosin
actin
Myosin: protein that makes up thick myofilaments
Actin: protein that makes up thin myofilaments
Transverse tubules
extend across the sarcoplasm
Formed from inward projections of the sarcolemma
Allow electrical impulses to travel deep into the cell
THICK FILAMENTS
Consists of hundreds of myosin molecules stacked together
Myosin head faces outward
Myosin molecule is shaped like a golf club
THIN FILAMENTS
Consist of 2 chains of actin
Look like string of beads
actin
tropomyosin and troponin
Actin
tropomyosin and troponin
Actin: contractile protein
Tropomyosin and troponin: proteins entwined with actin
STRUCTURE OF MYOFIBRIL
Thick and thin myofilaments stack together to form myofibrils
Sarcomere
units of contraction of the myofilaments of a muscle
Z-disc/z-line
a plate/disc that serves as an anchor point for thin myofilaments
cross-bridge
when myosin attaches to actin
*contraction occurs when…
*contraction occurs when the myosin head latches onto actin
Motor neuron
a nerve that can stimulate skeletal muscle to contract
Found in brainstem and spinal cord
Axons
carry impulses to skeletal muscles
Each branch stimulated a different muscle fiber
Neuromuscular junction
connection between motor neuron and a muscle fibre
Synaptic cleft
between end of the motor nerve and the muscle fiber
HOW MUSCLE FIBERS CONTRACT
- When an impulse reaches end of motor neuron and neurotransmitter is released acetylcholine (Ach) the neurotransmitter released into the synaptic cleft
- Ach stimulates receptors in the sarcolemma: membrane surrounding muscle fiber
- Electrical impulses sent over the sarcolemma along T tubules
- –T tubules cause the sacs in the sarcoplasmic reticulum to release calcium - The calcium binds with the troponin to expose attachment points on actin
- –The myosin heads of thick grab the thin and muscle contraction occurs
HOW MUSCLE FIBERS RELAX
- Ach is no longer released when nerve impulses stop arriving at the neuromuscular junction
- Acetylcholine esterase: breaks down remaining Ach
- Calcium ions are pumped back into the sarcoplasmic reticulum
- Troponin and tropomyosin prevent the myosin head from grasping the thin filament
- Muscle relaxes
Myasthenia
body produces antibodies against receptors for Ach nerve transmission is poor and profound muscular weakness
Tetanus
“lock jaw” bacteria which causes motor neurons to fire excessively leads to overstimulation of muscles resulting in severe muscle spasms
how MUSCLE TONE works
- Sarcomeres are shortened in overly contracted fibers
- -Fibers can’t contract very for before thick filaments bump into z-discs
- -Contractions are weak - An overly stretched fibers thin filaments have little overlap
- -Only small part of thin filament accessible for myosin heads to grab
- -Contractions are weak - When thin and thick filaments partially overlap contractions are strong
- -Z-discs are far enough apart to allow for movement during contraction
- -Thin/thick filaments overlap enough to allow the myosin head to grip the thin actin filaments
Muscle tone
continuous state of partial contraction
Allows you to stand, hold head up and maintain posture
Allows you to react quickly to a dangerous situation
Motor unit
one motor neuron and all the fibers (group) it stimulates
A single motor can consist of a few fibers or hundreds
These fibers are scattered throughout the muscle rather than bunched this allows contraction to be spread over wide area